Acyclic Stereoselective Boron Alkylation Reactions for the Asymmetric Synthesis of β-Substituted α-Amino Acid Derivatives

Optically active syn- or anti-β-substituted-α-amino acid derivatives are prepared in 94 to ≥99% ee and 66−98% ds by reaction of the Schiff base acetate of glycine tert-butyl ester with chiral, nonracemic B-alkyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine (CdOH) or cinch...

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Veröffentlicht in:	Journal of the American Chemical Society 2003-03, Vol.125 (9), p.2370-2371
Hauptverfasser:	O'Donnell, Martin J, Cooper, Jeremy T, Mader, Mary M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Amino Acids - chemical synthesis Aminobutyrates - chemistry Boranes - chemistry Chemical reactivity Chemistry Cinchona Alkaloids - chemistry Exact sciences and technology Isoleucine - analogs & derivatives Organic chemistry Reactivity and mechanisms Stereoisomerism Substrate Specificity
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