Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals

The cytotoxicity of alkenals towards hepatocytes was related to their electrophilicity not their hydrophobicity as cytotoxicity decreased as the chain length increased from acrolein to hexenal and then cytotoxicity increased from hexenal to nonenal. The sequence of events found was rapid glutathione...

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Veröffentlicht in:	Chemico-biological interactions 2003-02, Vol.143, p.107-117
Hauptverfasser:	Niknahad, Hossein, Siraki, Arno G, Shuhendler, Adam, Khan, Sumsullah, Teng, Shirley, Galati, Giuseppe, Easson, Elaine, Poon, Raymond, O'Brien, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Acrolein Aldehyde dehydrogenase Aldehyde Dehydrogenase - metabolism Aldehydes - pharmacology Aliphatic aldehydes Animals Cell death Hepatocytes - drug effects Hepatocytes - enzymology Isoenzymes Lipid peroxidation Male Rats Rats, Sprague-Dawley
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