Cross-Linking of 2-Deoxyribonolactone and Its β-Elimination Product by Base Excision Repair Enzymes

2-Deoxyribonolactone (3) is produced in DNA as a result of reaction with a variety of DNA damaging agents. The lesion undergoes β-elimination to form a second metastable electrophilic product (4). In this study, DNA containing 2-deoxyribonolactone (3) and its β-elimination product (4) are generated...

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Veröffentlicht in:	Biochemistry (Easton) 2003-03, Vol.42 (8), p.2449-2455
Hauptverfasser:	Kroeger, Kelly M, Hashimoto, Mitsumasa, Kow, Yoke Wah, Greenberg, Marc M
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Deoxyribonolactone 4-Butyrolactone - analogs & derivatives Base excision repair Binding Sites Carbon-Oxygen Lyases - antagonists & inhibitors Carbon-Oxygen Lyases - chemistry Cross-Linking Reagents - chemistry Deoxyribonuclease (Pyrimidine Dimer) DNA Damage DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase DNA-Formamidopyrimidine Glycosylase Endodeoxyribonucleases - chemistry Enzyme Inhibitors - chemistry Escherichia coli Escherichia coli Proteins - antagonists & inhibitors Escherichia coli Proteins - chemistry FPG protein Furans - chemistry Humans Hydrolysis N-Glycosyl Hydrolases - chemistry NEIL1 protein Nucleic Acid Heteroduplexes - antagonists & inhibitors Nucleic Acid Heteroduplexes - chemistry Sugar Acids - chemistry
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