Structure and allosteric regulation of the alpha X beta 2 integrin I domain

The integrin alpha X beta 2 (CD11c/CD18, p150,95) binds ligands through the I domain of the alpha X subunit. Ligands include the complement factor fragment iC3b, a key component in the innate immune defense, which, together with the expression of alpha X beta 2 on dendritic cells and on other leukoc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-02, Vol.100 (4), p.1873-1878
Hauptverfasser:	Vorup-Jensen, Thomas, Ostermeier, Christian, Shimaoka, Motomu, Hommel, Ulrich, Springer, Timothy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Amino Acid Sequence Base Sequence Crystallography, X-Ray DNA Primers Integrin alphaXbeta2 - chemistry Integrin alphaXbeta2 - genetics Integrin alphaXbeta2 - metabolism Molecular Sequence Data Protein Denaturation Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Surface Plasmon Resonance
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