Similarity between the vasorelaxing activity of dinitrosyl iron cysteine complexes and endothelium-derived relaxing factor

Dinitrosyl iron complexes with cysteine (DNIC) induced a concentration-dependent relaxation of pre-contracted (norepinephrine, 10 −7 M) de-endothelialized ring segments of rat aorta. The vasodilator response was more similar to acetycholine (ACh)-induced relaxation in intact aortic rings than to nit...

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Veröffentlicht in:	European journal of pharmacology 1992-02, Vol.211 (3), p.313-317
Hauptverfasser:	Vedernikov, Yuri P., Mordvintcev, Peter I., Malenkova, Irina V., Vanin, Anatoly F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Cysteine - analogs & derivatives Cysteine - pharmacology Dinitrosyl iron complexes (with cysteine) Drug Stability EDRF (endothelium-derived relaxing factor) Endothelium, Vascular - physiology Hemoglobins - pharmacology In Vitro Techniques Kinetics Muscle Relaxation - drug effects Muscle Tonus - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Nitric oxide (NO) Nitric Oxide - pharmacology Rats Rats, Inbred Strains Vasorelaxation
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