Studies Investigating Pretransplant Donor-Specific Blood Transfusion, Rapamycin, and the CD154-Specific Antibody IDEC-131 in a Nonhuman Primate Model of Skin Allotransplantation

Anti-CD154 variably prolongs allograft survival in nonhuman primates. Rodent studies suggest that adding pretransplant donor-specific transfusion (DST) and/or rapamycin to anti-CD154 improves survival. The CD154-specific Ab IDEC-131 was tested alone and in combination with rapamycin for its ability...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-03, Vol.170 (5), p.2776-2782
Hauptverfasser:	Xu, He, Montgomery, Sean P, Preston, Edwin H, Tadaki, Douglas K, Hale, Douglas A, Harlan, David M, Kirk, Allan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - therapeutic use Blood Transfusion - methods CD3 Complex - immunology CD40 Ligand - biosynthesis CD40 Ligand - immunology Cell Division - drug effects Cell Division - immunology Cells, Cultured Drug Therapy, Combination Endothelium, Vascular - cytology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Graft Enhancement, Immunologic - methods Humans Immune Tolerance Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - therapeutic use Injections, Intravenous Isoantibodies - biosynthesis Lymphocyte Culture Test, Mixed Macaca mulatta Models, Immunological Sirolimus - administration & dosage Sirolimus - therapeutic use Skin Transplantation - immunology Skin Transplantation - methods Skin Transplantation - pathology T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Transplantation Conditioning - methods
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