Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection
Although the mechanisms underlying ischemia/reperfusion injury remain elusive, evidence supports the etiologic role of intracellular calcium overload and oxidative stress induced by reactive oxygen species. Activation of the sodium hydrogen exchanger (NHE) is associated with intracellular calcium ac...
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| Veröffentlicht in: | The Annals of thoracic surgery 2003-02, Vol.75 (2), p.S700-S708 |
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| container_end_page | S708 |
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| container_issue | 2 |
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| container_title | The Annals of thoracic surgery |
| container_volume | 75 |
| creator | Mentzer, Robert M Lasley, Robert D Jessel, Andreas Karmazyn, Morris |
| description | Although the mechanisms underlying ischemia/reperfusion injury remain elusive, evidence supports the etiologic role of intracellular calcium overload and oxidative stress induced by reactive oxygen species. Activation of the sodium hydrogen exchanger (NHE) is associated with intracellular calcium accumulation. Inhibition of the NHE-1 isoform may attenuate the consequences of this injury. Although there is strong preclinical and early clinical evidence that NHE inhibitors may be cardioprotective, definitive proof of this concept in humans awaits the results of ongoing clinical trials. |
| doi_str_mv | 10.1016/S0003-4975(02)04700-8 |
| format | Article |
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Activation of the sodium hydrogen exchanger (NHE) is associated with intracellular calcium accumulation. Inhibition of the NHE-1 isoform may attenuate the consequences of this injury. Although there is strong preclinical and early clinical evidence that NHE inhibitors may be cardioprotective, definitive proof of this concept in humans awaits the results of ongoing clinical trials.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(02)04700-8</identifier><identifier>PMID: 12607715</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amiloride - pharmacology ; Animals ; Biological and medical sciences ; Cardiology. 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Activation of the sodium hydrogen exchanger (NHE) is associated with intracellular calcium accumulation. Inhibition of the NHE-1 isoform may attenuate the consequences of this injury. Although there is strong preclinical and early clinical evidence that NHE inhibitors may be cardioprotective, definitive proof of this concept in humans awaits the results of ongoing clinical trials.</description><subject>Amiloride - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Artery Bypass</subject><subject>Coronary heart disease</subject><subject>Creatine Kinase - blood</subject><subject>Diuretics - pharmacology</subject><subject>Guanidines - pharmacology</subject><subject>Heart</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ischemic Preconditioning, Myocardial</subject><subject>Medical sciences</subject><subject>Myocardial Reperfusion Injury - physiopathology</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Sodium-Hydrogen Exchangers - antagonists & inhibitors</subject><subject>Sodium-Hydrogen Exchangers - metabolism</subject><subject>Sodium-Hydrogen Exchangers - physiology</subject><subject>Sulfones - pharmacology</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMouj5-gtKLoodqnk17Ell8wYIH9RzSZOpG2lSTVtx_b_aBHj1NhvkmM_MhdEzwJcGkuHrGGLOcV1KcY3qBucQ4L7fQhAhB84KKahtNfpE9tB_je0ppKu-iPUILLCURE_Ty6IegDbTt2OqQxd66scvmCxv6N_AZfJu59m-QOT93tRtc7zPtbWZa553RbdYteqODden5EfoBzBI5RDuNbiMcbeIBer27fZk-5LOn-8fpzSw3nMohl6y0WvCmqZuiYmAAgwCrZVHSWnBRlSVoYongpC6EJoSIikjOrShswSS17ACdrf9Noz9HiIPqXFzeoj30Y1SSYU4EZgkUa9CEPsYAjfoIrtNhoQhWS51qpVMtXSlM1UqnKlPfyWbAWHdg_7o2_hJwugF0TDqaoL1x8Y_jgknMZOKu1xwkHV8OgorGgTdgXUjOlO3dP6v8ACtdkio</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Mentzer, Robert M</creator><creator>Lasley, Robert D</creator><creator>Jessel, Andreas</creator><creator>Karmazyn, Morris</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection</title><author>Mentzer, Robert M ; Lasley, Robert D ; Jessel, Andreas ; Karmazyn, Morris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-738da54ffbf693ece0e5eda7682b545988ea1d1541b65a111591744d56d6372d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amiloride - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Artery Bypass</topic><topic>Coronary heart disease</topic><topic>Creatine Kinase - blood</topic><topic>Diuretics - pharmacology</topic><topic>Guanidines - pharmacology</topic><topic>Heart</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ischemic Preconditioning, Myocardial</topic><topic>Medical sciences</topic><topic>Myocardial Reperfusion Injury - physiopathology</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Sodium-Hydrogen Exchangers - antagonists & inhibitors</topic><topic>Sodium-Hydrogen Exchangers - metabolism</topic><topic>Sodium-Hydrogen Exchangers - physiology</topic><topic>Sulfones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mentzer, Robert M</creatorcontrib><creatorcontrib>Lasley, Robert D</creatorcontrib><creatorcontrib>Jessel, Andreas</creatorcontrib><creatorcontrib>Karmazyn, Morris</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mentzer, Robert M</au><au>Lasley, Robert D</au><au>Jessel, Andreas</au><au>Karmazyn, Morris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>75</volume><issue>2</issue><spage>S700</spage><epage>S708</epage><pages>S700-S708</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><coden>ATHSAK</coden><abstract>Although the mechanisms underlying ischemia/reperfusion injury remain elusive, evidence supports the etiologic role of intracellular calcium overload and oxidative stress induced by reactive oxygen species. 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| ispartof | The Annals of thoracic surgery, 2003-02, Vol.75 (2), p.S700-S708 |
| issn | 0003-4975 1552-6259 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amiloride - pharmacology Animals Biological and medical sciences Cardiology. Vascular system Coronary Artery Bypass Coronary heart disease Creatine Kinase - blood Diuretics - pharmacology Guanidines - pharmacology Heart Humans Immunohistochemistry Ischemic Preconditioning, Myocardial Medical sciences Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Sodium-Hydrogen Exchangers - antagonists & inhibitors Sodium-Hydrogen Exchangers - metabolism Sodium-Hydrogen Exchangers - physiology Sulfones - pharmacology |
| title | Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection |
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