μ Opioid receptors and analgesia at the site of a peripheral nerve injury

Opioid ligands may exert antinociception through receptors expressed on peripheral afferent axons. Whether local opioid receptors might attenuate neuropathic pain is uncertain. In this work, we examined the function and expression of local μ opioid receptors (MORs) associated with the chronic constr...

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Veröffentlicht in:	Annals of neurology 2003-03, Vol.53 (3), p.366-375
Hauptverfasser:	Truong, Wayne, Cheng, Chu, Xu, Qing-Gui, Li, Xia-Qing, Zochodne, Douglas W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia - methods Analgesics Animals Axons - chemistry Axons - metabolism Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Dose-Response Relationship, Drug Male Medical sciences Morphine - pharmacology Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pain Measurement - drug effects Pain Measurement - methods Peripheral Nerve Injuries Peripheral Nerves - chemistry Peripheral Nerves - metabolism Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, Opioid, mu - analysis Receptors, Opioid, mu - biosynthesis Sciatic Neuropathy - metabolism
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