Penetration of human skin by the cercariae of Schistosoma mansoni: an investigation of the effect of multiple cercarial applications
It has previously been postulated that L-arginine emitted by penetrating Schistosoma mansoni cercariae serves as an intraspecific signal guiding other cercariae to the penetration site. It was suggested that penetrating in groups offers a selective advantage. If this hypothesis is correct and group...
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| Veröffentlicht in: | Journal of helminthology 2003-03, Vol.77 (1), p.27-31 |
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| container_title | Journal of helminthology |
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| creator | Ingram, R.J. Bartlett, A. Brown, M.B. Marriott, C. Whitfield, P.J. |
| description | It has previously been postulated that L-arginine emitted by penetrating Schistosoma mansoni cercariae serves as an intraspecific signal guiding other cercariae to the penetration site. It was suggested that penetrating in groups offers a selective advantage. If this hypothesis is correct and group penetration at one site on the host offers an advantage, it would follow that at such a site, successive groups of cercariae would be able to penetrate skin in either greater numbers or at a faster rate. This prediction was tested by the use of an in vitro model of cercarial penetration based on the Franz cell and using human skin. It was demonstrated that there was no increase in the percentage of cercariae able to penetrate the skin with subsequent exposures. Consequently, it seems unlikely that the release of L-arginine by cercariae during penetration could have evolved as a specific orientation system based on a selective advantage offered by group penetration. |
| doi_str_mv | 10.1079/JOH2002157 |
| format | Article |
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It was suggested that penetrating in groups offers a selective advantage. If this hypothesis is correct and group penetration at one site on the host offers an advantage, it would follow that at such a site, successive groups of cercariae would be able to penetrate skin in either greater numbers or at a faster rate. This prediction was tested by the use of an in vitro model of cercarial penetration based on the Franz cell and using human skin. It was demonstrated that there was no increase in the percentage of cercariae able to penetrate the skin with subsequent exposures. Consequently, it seems unlikely that the release of L-arginine by cercariae during penetration could have evolved as a specific orientation system based on a selective advantage offered by group penetration.</description><identifier>ISSN: 0022-149X</identifier><identifier>EISSN: 1475-2697</identifier><identifier>DOI: 10.1079/JOH2002157</identifier><identifier>PMID: 12590661</identifier><identifier>CODEN: JOHLAT</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Arginine - metabolism ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Host parasite relation; pathogenicity ; Humans ; Invertebrates ; Larva ; Nemathelminthia. Plathelmintha ; Parasitology - methods ; Schistosoma mansoni - metabolism ; Schistosoma mansoni - physiology ; Skin - parasitology</subject><ispartof>Journal of helminthology, 2003-03, Vol.77 (1), p.27-31</ispartof><rights>Cambridge University Press 2003</rights><rights>2003 INIST-CNRS</rights><rights>Cambridge University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-a84f0e6e5c7a4954be3f92c037840245710f776f9d6864081cfa080ede18ce573</citedby><cites>FETCH-LOGICAL-c451t-a84f0e6e5c7a4954be3f92c037840245710f776f9d6864081cfa080ede18ce573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022149X03000064/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14587177$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12590661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ingram, R.J.</creatorcontrib><creatorcontrib>Bartlett, A.</creatorcontrib><creatorcontrib>Brown, M.B.</creatorcontrib><creatorcontrib>Marriott, C.</creatorcontrib><creatorcontrib>Whitfield, P.J.</creatorcontrib><title>Penetration of human skin by the cercariae of Schistosoma mansoni: an investigation of the effect of multiple cercarial applications</title><title>Journal of helminthology</title><addtitle>J. Helminthol</addtitle><description>It has previously been postulated that L-arginine emitted by penetrating Schistosoma mansoni cercariae serves as an intraspecific signal guiding other cercariae to the penetration site. It was suggested that penetrating in groups offers a selective advantage. If this hypothesis is correct and group penetration at one site on the host offers an advantage, it would follow that at such a site, successive groups of cercariae would be able to penetrate skin in either greater numbers or at a faster rate. This prediction was tested by the use of an in vitro model of cercarial penetration based on the Franz cell and using human skin. It was demonstrated that there was no increase in the percentage of cercariae able to penetrate the skin with subsequent exposures. Consequently, it seems unlikely that the release of L-arginine by cercariae during penetration could have evolved as a specific orientation system based on a selective advantage offered by group penetration.</description><subject>Animals</subject><subject>Arginine - metabolism</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Host parasite relation; pathogenicity</subject><subject>Humans</subject><subject>Invertebrates</subject><subject>Larva</subject><subject>Nemathelminthia. Plathelmintha</subject><subject>Parasitology - methods</subject><subject>Schistosoma mansoni - metabolism</subject><subject>Schistosoma mansoni - physiology</subject><subject>Skin - parasitology</subject><issn>0022-149X</issn><issn>1475-2697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkV1rFTEQhoMo9rR64w-QRdALcXWSzcfGOym2VQpVVPAu5ORMetLuV5PdYu_94WY9Sw-INxNm5pmXN7yEPKPwloLS7z5fnDEARoV6QFaUK1EyqdVDsspDVlKufx6Qw5SuAKCiTDwmB7lqkJKuyO8v2OEY7Rj6ruh9sZ1a2xXpOnTF-q4Yt1g4jM7GYHFef3PbkMY-9a0tMpj6Lrwv8kHobjGN4fJeZ75E79GNc9dOzRiGZi_WFHYYmuD-8ukJeeRtk_Dp8h6RHycfvx-flecXp5-OP5yXjgs6lrbmHlCicMpyLfgaK6-Zg0rVHBgXioJXSnq9kbXkUFPnLdSAG6S1Q6GqI_JqpzvE_mbKhk0bksOmsR32UzKqAk4Z4xl88Q941U-xy94MoxXXNWiRodc7yMU-pYjeDDG0Nt4ZCmYOxuyDyfDzRXFat7jZo0sSGXi5ADY52_hoOxfSnuOiVlTNQuWOyzngr_u9jddGqkoJI0-_Gio4gJbKnGT-zeLStusYNpe4_8t_fP4B5oiydg</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Ingram, R.J.</creator><creator>Bartlett, A.</creator><creator>Brown, M.B.</creator><creator>Marriott, C.</creator><creator>Whitfield, P.J.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7SN</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H95</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Penetration of human skin by the cercariae of Schistosoma mansoni: an investigation of the effect of multiple cercarial applications</title><author>Ingram, R.J. ; Bartlett, A. ; Brown, M.B. ; Marriott, C. ; Whitfield, P.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-a84f0e6e5c7a4954be3f92c037840245710f776f9d6864081cfa080ede18ce573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Arginine - metabolism</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Host parasite relation; pathogenicity</topic><topic>Humans</topic><topic>Invertebrates</topic><topic>Larva</topic><topic>Nemathelminthia. 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Helminthol</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>77</volume><issue>1</issue><spage>27</spage><epage>31</epage><pages>27-31</pages><issn>0022-149X</issn><eissn>1475-2697</eissn><coden>JOHLAT</coden><abstract>It has previously been postulated that L-arginine emitted by penetrating Schistosoma mansoni cercariae serves as an intraspecific signal guiding other cercariae to the penetration site. It was suggested that penetrating in groups offers a selective advantage. If this hypothesis is correct and group penetration at one site on the host offers an advantage, it would follow that at such a site, successive groups of cercariae would be able to penetrate skin in either greater numbers or at a faster rate. This prediction was tested by the use of an in vitro model of cercarial penetration based on the Franz cell and using human skin. It was demonstrated that there was no increase in the percentage of cercariae able to penetrate the skin with subsequent exposures. Consequently, it seems unlikely that the release of L-arginine by cercariae during penetration could have evolved as a specific orientation system based on a selective advantage offered by group penetration.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>12590661</pmid><doi>10.1079/JOH2002157</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of helminthology, 2003-03, Vol.77 (1), p.27-31 |
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| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Animals Arginine - metabolism Biological and medical sciences Fundamental and applied biological sciences. Psychology Host parasite relation pathogenicity Humans Invertebrates Larva Nemathelminthia. Plathelmintha Parasitology - methods Schistosoma mansoni - metabolism Schistosoma mansoni - physiology Skin - parasitology |
| title | Penetration of human skin by the cercariae of Schistosoma mansoni: an investigation of the effect of multiple cercarial applications |
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