Repeated anticonvulsant testing: contingent tolerance to diazepam and clobazam in kindled rats

The acute anticonvulsant efficacy of diazapam (1.5 mg/kg i.p.) was evaluated by repeated test injection in kindled rats subcutaneously implanted with diazepam-filled or empty silastic tubes for 3 weeks. Tolerance developed to acute test injections in both diazepam- and sham-implanted rats. Tolerance...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Epilepsy research 1992-04, Vol.11 (2), p.89-101
1. Verfasser:	Tietz, Elizabeth I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents Anticonvulsant effect Anticonvulsants - pharmacology Benzodiazepines Benzodiazepinones - pharmacology Biological and medical sciences Clobazam Contingent tolerance Diazepam Diazepam - pharmacology Drug Tolerance Flumazenil - pharmacology Fundamental and applied biological sciences. Psychology Kindling, Neurologic - drug effects Male Radioligand Assay Rats Rats, Inbred Strains Seizures - physiopathology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!