Enterotoxigenic Bacteroides Fragilis: Epidemiologic Studies of its Role as a Human Diarrhoeal Pathogen
Strains of Bacteroides fragilis which produce enterotoxin(s) (ETBF) have been associated with diarrhoeal diseases in young domestic animals and have also been isolated from humans with diarrhoea. We have determined epidemiologically that ETBF are significantly associated with diarrhoea in humans. We...
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| Veröffentlicht in: | Journal of diarrhoeal diseases research 1992-03, Vol.10 (1), p.4-9 |
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| creator | Sack, R Bradley Myers, Lyle L Almeido - Hill, Janne' Shoop, Douglas S Bradbury, Wayne C Reid, Raymond Santosham, Mathuram |
| description | Strains of Bacteroides fragilis which produce enterotoxin(s) (ETBF) have been associated with diarrhoeal diseases in young domestic animals and have also been isolated from humans with diarrhoea. We have determined epidemiologically that ETBF are significantly associated with diarrhoea in humans. We studied Apaches, primarily children, with diarrhoea attending an outpatient facility in Whiteriver, Arizona, from July 1986 through July, 1988. Stool cultures for isolation of ETBF and other diarrhoeal pathogens were taken from these persons as well as from age and time — matched control persons who did not have diarrhoea. ETBF were isolated significantly more often from persons with diarrhoea (12%) than from controls (6%), p=0.03. Isolation was highest (20—24% of stool cultures positive) during the second and third years of life. The diarrhoeal syndrome associated with ETBF was non—specific, and most characteristic of a secretory, rather than inflammatory, type of diarrhoea. ETBF are significantly associated with acute diarrhoea in Apache children, and may be an important newly described cause of diarrhoea in humans. |
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We have determined epidemiologically that ETBF are significantly associated with diarrhoea in humans. We studied Apaches, primarily children, with diarrhoea attending an outpatient facility in Whiteriver, Arizona, from July 1986 through July, 1988. Stool cultures for isolation of ETBF and other diarrhoeal pathogens were taken from these persons as well as from age and time — matched control persons who did not have diarrhoea. ETBF were isolated significantly more often from persons with diarrhoea (12%) than from controls (6%), p=0.03. Isolation was highest (20—24% of stool cultures positive) during the second and third years of life. The diarrhoeal syndrome associated with ETBF was non—specific, and most characteristic of a secretory, rather than inflammatory, type of diarrhoea. ETBF are significantly associated with acute diarrhoea in Apache children, and may be an important newly described cause of diarrhoea in humans.</description><identifier>ISSN: 0253-8768</identifier><identifier>EISSN: 2311-8512</identifier><identifier>PMID: 1619243</identifier><language>eng</language><publisher>Bangladesh: International Centre for Diarrhoeal Disease Research</publisher><subject>Acute Disease ; Adolescent ; Adult ; Age Factors ; Age groups ; Arizona - epidemiology ; Bacterial diseases ; Bacteroides fragilis ; Bacteroides fragilis - metabolism ; Bacteroides Infections - epidemiology ; Child ; Child, Preschool ; Children ; Diarrhea ; Diarrhea - epidemiology ; Diarrhea, Infantile - epidemiology ; Diseases ; Enterotoxins ; Enterotoxins - biosynthesis ; Epidemiology ; Humans ; Infant ; Infant, Newborn ; Pathogens ; Specimens</subject><ispartof>Journal of diarrhoeal diseases research, 1992-03, Vol.10 (1), p.4-9</ispartof><rights>Copyright © 1991 International Centre for Diarrhoeal Disease Research</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23498244$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23498244$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1619243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sack, R Bradley</creatorcontrib><creatorcontrib>Myers, Lyle L</creatorcontrib><creatorcontrib>Almeido - Hill, Janne'</creatorcontrib><creatorcontrib>Shoop, Douglas S</creatorcontrib><creatorcontrib>Bradbury, Wayne C</creatorcontrib><creatorcontrib>Reid, Raymond</creatorcontrib><creatorcontrib>Santosham, Mathuram</creatorcontrib><title>Enterotoxigenic Bacteroides Fragilis: Epidemiologic Studies of its Role as a Human Diarrhoeal Pathogen</title><title>Journal of diarrhoeal diseases research</title><addtitle>J Diarrhoeal Dis Res</addtitle><description>Strains of Bacteroides fragilis which produce enterotoxin(s) (ETBF) have been associated with diarrhoeal diseases in young domestic animals and have also been isolated from humans with diarrhoea. We have determined epidemiologically that ETBF are significantly associated with diarrhoea in humans. We studied Apaches, primarily children, with diarrhoea attending an outpatient facility in Whiteriver, Arizona, from July 1986 through July, 1988. Stool cultures for isolation of ETBF and other diarrhoeal pathogens were taken from these persons as well as from age and time — matched control persons who did not have diarrhoea. ETBF were isolated significantly more often from persons with diarrhoea (12%) than from controls (6%), p=0.03. Isolation was highest (20—24% of stool cultures positive) during the second and third years of life. The diarrhoeal syndrome associated with ETBF was non—specific, and most characteristic of a secretory, rather than inflammatory, type of diarrhoea. ETBF are significantly associated with acute diarrhoea in Apache children, and may be an important newly described cause of diarrhoea in humans.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Age groups</subject><subject>Arizona - epidemiology</subject><subject>Bacterial diseases</subject><subject>Bacteroides fragilis</subject><subject>Bacteroides fragilis - metabolism</subject><subject>Bacteroides Infections - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Diarrhea</subject><subject>Diarrhea - epidemiology</subject><subject>Diarrhea, Infantile - epidemiology</subject><subject>Diseases</subject><subject>Enterotoxins</subject><subject>Enterotoxins - biosynthesis</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Pathogens</subject><subject>Specimens</subject><issn>0253-8768</issn><issn>2311-8512</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LwzAUhoMoc05_gpAr7wr5bFLvdG5OGCh-XJe0Pdky2mYmKbh_b8Wh5-aF93l4L84JmjJOaaYlZadoSpjkmVa5PkcXMe4I4ZJqNkETmtOCCT5FdtEnCD75L7eB3tX43tQ_hWsg4mUwG9e6eIsX-7HonG_9ZnTe0tC4kXuLXYr41beATcQGr4bO9PjBmRC2HkyLX0za-nH4Ep1Z00a4OuYMfSwX7_NVtn5-fJrfrbMdFTxlijKASipNgNdWC1uwPIdGWiW0lZUiRJGmzkmhx2NQKMHzqpA1GEulaASfoZvf3X3wnwPEVHYu1tC2pgc_xFJxIohUZBSvj-JQddCU--A6Ew7l8TH_fBeTD3-YcVFoJgT_BgZvadM</recordid><startdate>199203</startdate><enddate>199203</enddate><creator>Sack, R Bradley</creator><creator>Myers, Lyle L</creator><creator>Almeido - Hill, Janne'</creator><creator>Shoop, Douglas S</creator><creator>Bradbury, Wayne C</creator><creator>Reid, Raymond</creator><creator>Santosham, Mathuram</creator><general>International Centre for Diarrhoeal Disease Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199203</creationdate><title>Enterotoxigenic Bacteroides Fragilis: Epidemiologic Studies of its Role as a Human Diarrhoeal Pathogen</title><author>Sack, R Bradley ; Myers, Lyle L ; Almeido - Hill, Janne' ; Shoop, Douglas S ; Bradbury, Wayne C ; Reid, Raymond ; Santosham, Mathuram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j143t-712eeb5780e3cf84f9266ed5f748f5b70070dc60988882e97436b95ceaf154d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Age groups</topic><topic>Arizona - epidemiology</topic><topic>Bacterial diseases</topic><topic>Bacteroides fragilis</topic><topic>Bacteroides fragilis - metabolism</topic><topic>Bacteroides Infections - epidemiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Diarrhea</topic><topic>Diarrhea - epidemiology</topic><topic>Diarrhea, Infantile - epidemiology</topic><topic>Diseases</topic><topic>Enterotoxins</topic><topic>Enterotoxins - biosynthesis</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Pathogens</topic><topic>Specimens</topic><toplevel>online_resources</toplevel><creatorcontrib>Sack, R Bradley</creatorcontrib><creatorcontrib>Myers, Lyle L</creatorcontrib><creatorcontrib>Almeido - Hill, Janne'</creatorcontrib><creatorcontrib>Shoop, Douglas S</creatorcontrib><creatorcontrib>Bradbury, Wayne C</creatorcontrib><creatorcontrib>Reid, Raymond</creatorcontrib><creatorcontrib>Santosham, Mathuram</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diarrhoeal diseases research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sack, R Bradley</au><au>Myers, Lyle L</au><au>Almeido - Hill, Janne'</au><au>Shoop, Douglas S</au><au>Bradbury, Wayne C</au><au>Reid, Raymond</au><au>Santosham, Mathuram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enterotoxigenic Bacteroides Fragilis: Epidemiologic Studies of its Role as a Human Diarrhoeal Pathogen</atitle><jtitle>Journal of diarrhoeal diseases research</jtitle><addtitle>J Diarrhoeal Dis Res</addtitle><date>1992-03</date><risdate>1992</risdate><volume>10</volume><issue>1</issue><spage>4</spage><epage>9</epage><pages>4-9</pages><issn>0253-8768</issn><eissn>2311-8512</eissn><abstract>Strains of Bacteroides fragilis which produce enterotoxin(s) (ETBF) have been associated with diarrhoeal diseases in young domestic animals and have also been isolated from humans with diarrhoea. We have determined epidemiologically that ETBF are significantly associated with diarrhoea in humans. We studied Apaches, primarily children, with diarrhoea attending an outpatient facility in Whiteriver, Arizona, from July 1986 through July, 1988. Stool cultures for isolation of ETBF and other diarrhoeal pathogens were taken from these persons as well as from age and time — matched control persons who did not have diarrhoea. ETBF were isolated significantly more often from persons with diarrhoea (12%) than from controls (6%), p=0.03. Isolation was highest (20—24% of stool cultures positive) during the second and third years of life. The diarrhoeal syndrome associated with ETBF was non—specific, and most characteristic of a secretory, rather than inflammatory, type of diarrhoea. ETBF are significantly associated with acute diarrhoea in Apache children, and may be an important newly described cause of diarrhoea in humans.</abstract><cop>Bangladesh</cop><pub>International Centre for Diarrhoeal Disease Research</pub><pmid>1619243</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Journal of diarrhoeal diseases research, 1992-03, Vol.10 (1), p.4-9 |
| issn | 0253-8768 2311-8512 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Acute Disease Adolescent Adult Age Factors Age groups Arizona - epidemiology Bacterial diseases Bacteroides fragilis Bacteroides fragilis - metabolism Bacteroides Infections - epidemiology Child Child, Preschool Children Diarrhea Diarrhea - epidemiology Diarrhea, Infantile - epidemiology Diseases Enterotoxins Enterotoxins - biosynthesis Epidemiology Humans Infant Infant, Newborn Pathogens Specimens |
| title | Enterotoxigenic Bacteroides Fragilis: Epidemiologic Studies of its Role as a Human Diarrhoeal Pathogen |
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