PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
We analyzed the PRNP M129V polymorphism in a Dutch population‐based early‐onset Alzheimer's disease sample. We observed a significant association between early‐onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1–3.3; p = 0.02) with t...
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| Veröffentlicht in: | Annals of neurology 2003-03, Vol.53 (3), p.409-412 |
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| container_title | Annals of neurology |
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| creator | Dermaut, Bart Croes, Esther A. Rademakers, Rosa Van Den Broeck, Marleen Cruts, Marc Hofman, Albert Van Duijn, Cornelia M. Van Broeckhoven, Christine |
| description | We analyzed the PRNP M129V polymorphism in a Dutch population‐based early‐onset Alzheimer's disease sample. We observed a significant association between early‐onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1–3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4–7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3–5.3; p < 0.01) and 3.5 (95% CI, 1.3–9.3; p = 0.01), respectively. Ann Neurol 2003;53;409–412 |
| doi_str_mv | 10.1002/ana.10507 |
| format | Article |
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We observed a significant association between early‐onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1–3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4–7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3–5.3; p < 0.01) and 3.5 (95% CI, 1.3–9.3; p = 0.01), respectively. Ann Neurol 2003;53;409–412</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.10507</identifier><identifier>PMID: 12601712</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Alleles ; Alzheimer Disease - genetics ; Amyloid - genetics ; Biological and medical sciences ; Chi-Square Distribution ; Confidence Intervals ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Genotype ; Homozygote ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Odds Ratio ; Prion Proteins ; Prions - genetics ; Protein Precursors - genetics ; Risk Factors</subject><ispartof>Annals of neurology, 2003-03, Vol.53 (3), p.409-412</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4907-310768a1e9389a476331f1f1a7bcdc912b85109c69176c3fc91e54d3098295083</citedby><cites>FETCH-LOGICAL-c4907-310768a1e9389a476331f1f1a7bcdc912b85109c69176c3fc91e54d3098295083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.10507$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.10507$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14612095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12601712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dermaut, Bart</creatorcontrib><creatorcontrib>Croes, Esther A.</creatorcontrib><creatorcontrib>Rademakers, Rosa</creatorcontrib><creatorcontrib>Van Den Broeck, Marleen</creatorcontrib><creatorcontrib>Cruts, Marc</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Van Duijn, Cornelia M.</creatorcontrib><creatorcontrib>Van Broeckhoven, Christine</creatorcontrib><title>PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>We analyzed the PRNP M129V polymorphism in a Dutch population‐based early‐onset Alzheimer's disease sample. We observed a significant association between early‐onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1–3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4–7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3–5.3; p < 0.01) and 3.5 (95% CI, 1.3–9.3; p = 0.01), respectively. Ann Neurol 2003;53;409–412</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Alzheimer Disease - genetics</subject><subject>Amyloid - genetics</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Confidence Intervals</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Genotype</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Prion Proteins</subject><subject>Prions - genetics</subject><subject>Protein Precursors - genetics</subject><subject>Risk Factors</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1PGzEQBmCroioh9MAfQHuhiMOWmfXaXh-jqIQGFFDV0qPlOF4w7EfwJILl13dpUjhVc_DIemZGehk7QPiKANmpbWzfCFAf2AAFx7TIcr3DBsBlngrk-S7bI7oHAC0RPrFdzCSgwmzALq5_zK6TG1thppO7tm5futuWwqpLQuOit-QpiYEekrKNibex6tK2Ib9KRtXLnQ-1j8eULAK9yn32sbQV-c_bd8h-nX37OT5PL68m38ejy9TlGlTKEZQsLHrNC21zJTnHsi-r5m7hNGbzQiBoJzUq6XjZf3mRLzjoItMCCj5kXzZ7l7F9XHtamTqQ81VlG9-uySgOOYDEHp5soIstUfSlWcZQ29gZBPOanOmTM3-T6-3hdul6XvvFu9xG1YOjLbDkbFVG27hA7y6XmIEWvTvduKdQ-e7_F81oNvp3Ot1MBFr557cJGx-MVFwJ83s2MWN-I6bFdGLO-R_2ZJDv</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>Dermaut, Bart</creator><creator>Croes, Esther A.</creator><creator>Rademakers, Rosa</creator><creator>Van Den Broeck, Marleen</creator><creator>Cruts, Marc</creator><creator>Hofman, Albert</creator><creator>Van Duijn, Cornelia M.</creator><creator>Van Broeckhoven, Christine</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease</title><author>Dermaut, Bart ; Croes, Esther A. ; Rademakers, Rosa ; Van Den Broeck, Marleen ; Cruts, Marc ; Hofman, Albert ; Van Duijn, Cornelia M. ; Van Broeckhoven, Christine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4907-310768a1e9389a476331f1f1a7bcdc912b85109c69176c3fc91e54d3098295083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Alzheimer Disease - genetics</topic><topic>Amyloid - genetics</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Confidence Intervals</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Genotype</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Prion Proteins</topic><topic>Prions - genetics</topic><topic>Protein Precursors - genetics</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dermaut, Bart</creatorcontrib><creatorcontrib>Croes, Esther A.</creatorcontrib><creatorcontrib>Rademakers, Rosa</creatorcontrib><creatorcontrib>Van Den Broeck, Marleen</creatorcontrib><creatorcontrib>Cruts, Marc</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Van Duijn, Cornelia M.</creatorcontrib><creatorcontrib>Van Broeckhoven, Christine</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dermaut, Bart</au><au>Croes, Esther A.</au><au>Rademakers, Rosa</au><au>Van Den Broeck, Marleen</au><au>Cruts, Marc</au><au>Hofman, Albert</au><au>Van Duijn, Cornelia M.</au><au>Van Broeckhoven, Christine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2003-03</date><risdate>2003</risdate><volume>53</volume><issue>3</issue><spage>409</spage><epage>412</epage><pages>409-412</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>We analyzed the PRNP M129V polymorphism in a Dutch population‐based early‐onset Alzheimer's disease sample. We observed a significant association between early‐onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1–3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4–7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3–5.3; p < 0.01) and 3.5 (95% CI, 1.3–9.3; p = 0.01), respectively. Ann Neurol 2003;53;409–412</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12601712</pmid><doi>10.1002/ana.10507</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Alleles Alzheimer Disease - genetics Amyloid - genetics Biological and medical sciences Chi-Square Distribution Confidence Intervals Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Genotype Homozygote Humans Male Medical sciences Middle Aged Neurology Odds Ratio Prion Proteins Prions - genetics Protein Precursors - genetics Risk Factors |
| title | PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease |
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