Genetic evolution of human immunodeficiency virus type 1 in two spouses responding successfully to highly active antiretroviral therapy
The current case study provided an unusual setting to track the evolution of HIV-1 envelope gene over a maximum period of 6 years in two asymptomatic spouses undergoing suppressive highly active antiretroviral therapy. For this purpose, proviral DNA samples taken from uncultured peripheral blood mon...
Gespeichert in:
| Veröffentlicht in: | AIDS research and human retroviruses 2003, Vol.19 (1), p.65-71 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 71 |
|---|---|
| container_issue | 1 |
| container_start_page | 65 |
| container_title | AIDS research and human retroviruses |
| container_volume | 19 |
| creator | ANASTASSOPOULOU, Cleo G PARASKEVIS, Dimitrios SYPSA, Vassiliki-Anastasia CHRYSSOU, Stella-Eugenie ANTONIADOU, Anastasia GIAMARELOU, Helen HATZAKIS, Angelos |
| description | The current case study provided an unusual setting to track the evolution of HIV-1 envelope gene over a maximum period of 6 years in two asymptomatic spouses undergoing suppressive highly active antiretroviral therapy. For this purpose, proviral DNA samples taken from uncultured peripheral blood mononuclear cells and spanning the C2-V5 regions of env were analyzed at three sampling points per subject. Two distinct topological patterns were observed in the phylogenetic reconstructions of the genetically linked sequences of the couple: an intermingled pattern and a sequentially shifting pattern in the virus populations of the male index case and his spouse, respectively. Application of three evolutionary models for the amino acid-encoded sites, using the maximum likelihood approach, indicated the operation of positive selection in the region only at the second time point in the woman, before receiving therapy. These findings reinforce the evidence of a crucial role for host-selective constraints on HIV-1 env evolution in vivo. |
| doi_str_mv | 10.1089/08892220360473989 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73039568</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18717396</sourcerecordid><originalsourceid>FETCH-LOGICAL-c358t-5cf32c3cf8cdda42bd9f875b7bef4da26eb56c7729ca3c11419238981133efd03</originalsourceid><addsrcrecordid>eNqFkc1u1TAQhS0EopfCA7BB3sAuxT9xbC9RBQWpUjewjhxn3GuU2ME_F-UJeG1c9UpdsGA1R5rvHGnmIPSWkitKlP5IlNKMMcIH0kuulX6GDlRz2qmeiOfo8LDvGqAv0KucfxJCGi5eogvKhB4kEwf05wYCFG8xnOJSi48BR4ePdTUB-3WtIc7gvPUQ7I5PPtWMy74BptgHXH5HnLdYM2ScoKkw-3CPc7UWcnZ1WXZcIj76-2NTxhZ_AmxC8QlKii3NLLgcIZltf41eOLNkeHOel-jHl8_fr792t3c3364_3XaWC1U6YR1nllun7Dybnk2zdkqKSU7g-tmwASYxWCmZtoZbSnuqGVdaUco5uJnwS_ThMXdL8VeFXMbVZwvLYgK0Q0bJCddiUP8FqZK0_XxoIH0EbYo5J3Djlvxq0j5SMj7UNP5TU_O8O4fXaYX5yXHupQHvz4DJ1iwumWB9fuJ6QaTWlP8FNiWeFQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18717396</pqid></control><display><type>article</type><title>Genetic evolution of human immunodeficiency virus type 1 in two spouses responding successfully to highly active antiretroviral therapy</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>ANASTASSOPOULOU, Cleo G ; PARASKEVIS, Dimitrios ; SYPSA, Vassiliki-Anastasia ; CHRYSSOU, Stella-Eugenie ; ANTONIADOU, Anastasia ; GIAMARELOU, Helen ; HATZAKIS, Angelos</creator><creatorcontrib>ANASTASSOPOULOU, Cleo G ; PARASKEVIS, Dimitrios ; SYPSA, Vassiliki-Anastasia ; CHRYSSOU, Stella-Eugenie ; ANTONIADOU, Anastasia ; GIAMARELOU, Helen ; HATZAKIS, Angelos</creatorcontrib><description>The current case study provided an unusual setting to track the evolution of HIV-1 envelope gene over a maximum period of 6 years in two asymptomatic spouses undergoing suppressive highly active antiretroviral therapy. For this purpose, proviral DNA samples taken from uncultured peripheral blood mononuclear cells and spanning the C2-V5 regions of env were analyzed at three sampling points per subject. Two distinct topological patterns were observed in the phylogenetic reconstructions of the genetically linked sequences of the couple: an intermingled pattern and a sequentially shifting pattern in the virus populations of the male index case and his spouse, respectively. Application of three evolutionary models for the amino acid-encoded sites, using the maximum likelihood approach, indicated the operation of positive selection in the region only at the second time point in the woman, before receiving therapy. These findings reinforce the evidence of a crucial role for host-selective constraints on HIV-1 env evolution in vivo.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/08892220360473989</identifier><identifier>PMID: 12596725</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Antiretroviral Therapy, Highly Active ; Biological and medical sciences ; DNA, Viral - analysis ; DNA, Viral - genetics ; Evolution, Molecular ; Female ; Genes, env ; HIV Infections - drug therapy ; HIV Infections - virology ; HIV-1 - genetics ; Human viral diseases ; Humans ; Infectious diseases ; Likelihood Functions ; Male ; Medical sciences ; Molecular Sequence Data ; Phylogeny ; Selection, Genetic ; Sequence Analysis, DNA ; Spouses ; Treatment Outcome ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS research and human retroviruses, 2003, Vol.19 (1), p.65-71</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-5cf32c3cf8cdda42bd9f875b7bef4da26eb56c7729ca3c11419238981133efd03</citedby><cites>FETCH-LOGICAL-c358t-5cf32c3cf8cdda42bd9f875b7bef4da26eb56c7729ca3c11419238981133efd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14507991$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12596725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ANASTASSOPOULOU, Cleo G</creatorcontrib><creatorcontrib>PARASKEVIS, Dimitrios</creatorcontrib><creatorcontrib>SYPSA, Vassiliki-Anastasia</creatorcontrib><creatorcontrib>CHRYSSOU, Stella-Eugenie</creatorcontrib><creatorcontrib>ANTONIADOU, Anastasia</creatorcontrib><creatorcontrib>GIAMARELOU, Helen</creatorcontrib><creatorcontrib>HATZAKIS, Angelos</creatorcontrib><title>Genetic evolution of human immunodeficiency virus type 1 in two spouses responding successfully to highly active antiretroviral therapy</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>The current case study provided an unusual setting to track the evolution of HIV-1 envelope gene over a maximum period of 6 years in two asymptomatic spouses undergoing suppressive highly active antiretroviral therapy. For this purpose, proviral DNA samples taken from uncultured peripheral blood mononuclear cells and spanning the C2-V5 regions of env were analyzed at three sampling points per subject. Two distinct topological patterns were observed in the phylogenetic reconstructions of the genetically linked sequences of the couple: an intermingled pattern and a sequentially shifting pattern in the virus populations of the male index case and his spouse, respectively. Application of three evolutionary models for the amino acid-encoded sites, using the maximum likelihood approach, indicated the operation of positive selection in the region only at the second time point in the woman, before receiving therapy. These findings reinforce the evidence of a crucial role for host-selective constraints on HIV-1 env evolution in vivo.</description><subject>AIDS/HIV</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Biological and medical sciences</subject><subject>DNA, Viral - analysis</subject><subject>DNA, Viral - genetics</subject><subject>Evolution, Molecular</subject><subject>Female</subject><subject>Genes, env</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Likelihood Functions</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>Selection, Genetic</subject><subject>Sequence Analysis, DNA</subject><subject>Spouses</subject><subject>Treatment Outcome</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EopfCA7BB3sAuxT9xbC9RBQWpUjewjhxn3GuU2ME_F-UJeG1c9UpdsGA1R5rvHGnmIPSWkitKlP5IlNKMMcIH0kuulX6GDlRz2qmeiOfo8LDvGqAv0KucfxJCGi5eogvKhB4kEwf05wYCFG8xnOJSi48BR4ePdTUB-3WtIc7gvPUQ7I5PPtWMy74BptgHXH5HnLdYM2ScoKkw-3CPc7UWcnZ1WXZcIj76-2NTxhZ_AmxC8QlKii3NLLgcIZltf41eOLNkeHOel-jHl8_fr792t3c3364_3XaWC1U6YR1nllun7Dybnk2zdkqKSU7g-tmwASYxWCmZtoZbSnuqGVdaUco5uJnwS_ThMXdL8VeFXMbVZwvLYgK0Q0bJCddiUP8FqZK0_XxoIH0EbYo5J3Djlvxq0j5SMj7UNP5TU_O8O4fXaYX5yXHupQHvz4DJ1iwumWB9fuJ6QaTWlP8FNiWeFQ</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>ANASTASSOPOULOU, Cleo G</creator><creator>PARASKEVIS, Dimitrios</creator><creator>SYPSA, Vassiliki-Anastasia</creator><creator>CHRYSSOU, Stella-Eugenie</creator><creator>ANTONIADOU, Anastasia</creator><creator>GIAMARELOU, Helen</creator><creator>HATZAKIS, Angelos</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Genetic evolution of human immunodeficiency virus type 1 in two spouses responding successfully to highly active antiretroviral therapy</title><author>ANASTASSOPOULOU, Cleo G ; PARASKEVIS, Dimitrios ; SYPSA, Vassiliki-Anastasia ; CHRYSSOU, Stella-Eugenie ; ANTONIADOU, Anastasia ; GIAMARELOU, Helen ; HATZAKIS, Angelos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-5cf32c3cf8cdda42bd9f875b7bef4da26eb56c7729ca3c11419238981133efd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>AIDS/HIV</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Biological and medical sciences</topic><topic>DNA, Viral - analysis</topic><topic>DNA, Viral - genetics</topic><topic>Evolution, Molecular</topic><topic>Female</topic><topic>Genes, env</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - genetics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Likelihood Functions</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>Selection, Genetic</topic><topic>Sequence Analysis, DNA</topic><topic>Spouses</topic><topic>Treatment Outcome</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANASTASSOPOULOU, Cleo G</creatorcontrib><creatorcontrib>PARASKEVIS, Dimitrios</creatorcontrib><creatorcontrib>SYPSA, Vassiliki-Anastasia</creatorcontrib><creatorcontrib>CHRYSSOU, Stella-Eugenie</creatorcontrib><creatorcontrib>ANTONIADOU, Anastasia</creatorcontrib><creatorcontrib>GIAMARELOU, Helen</creatorcontrib><creatorcontrib>HATZAKIS, Angelos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ANASTASSOPOULOU, Cleo G</au><au>PARASKEVIS, Dimitrios</au><au>SYPSA, Vassiliki-Anastasia</au><au>CHRYSSOU, Stella-Eugenie</au><au>ANTONIADOU, Anastasia</au><au>GIAMARELOU, Helen</au><au>HATZAKIS, Angelos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic evolution of human immunodeficiency virus type 1 in two spouses responding successfully to highly active antiretroviral therapy</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2003</date><risdate>2003</risdate><volume>19</volume><issue>1</issue><spage>65</spage><epage>71</epage><pages>65-71</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>The current case study provided an unusual setting to track the evolution of HIV-1 envelope gene over a maximum period of 6 years in two asymptomatic spouses undergoing suppressive highly active antiretroviral therapy. For this purpose, proviral DNA samples taken from uncultured peripheral blood mononuclear cells and spanning the C2-V5 regions of env were analyzed at three sampling points per subject. Two distinct topological patterns were observed in the phylogenetic reconstructions of the genetically linked sequences of the couple: an intermingled pattern and a sequentially shifting pattern in the virus populations of the male index case and his spouse, respectively. Application of three evolutionary models for the amino acid-encoded sites, using the maximum likelihood approach, indicated the operation of positive selection in the region only at the second time point in the woman, before receiving therapy. These findings reinforce the evidence of a crucial role for host-selective constraints on HIV-1 env evolution in vivo.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>12596725</pmid><doi>10.1089/08892220360473989</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-2229 |
| ispartof | AIDS research and human retroviruses, 2003, Vol.19 (1), p.65-71 |
| issn | 0889-2229 1931-8405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73039568 |
| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Antiretroviral Therapy, Highly Active Biological and medical sciences DNA, Viral - analysis DNA, Viral - genetics Evolution, Molecular Female Genes, env HIV Infections - drug therapy HIV Infections - virology HIV-1 - genetics Human viral diseases Humans Infectious diseases Likelihood Functions Male Medical sciences Molecular Sequence Data Phylogeny Selection, Genetic Sequence Analysis, DNA Spouses Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Genetic evolution of human immunodeficiency virus type 1 in two spouses responding successfully to highly active antiretroviral therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T21%3A06%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20evolution%20of%20human%20immunodeficiency%20virus%20type%201%20in%20two%20spouses%20responding%20successfully%20to%20highly%20active%20antiretroviral%20therapy&rft.jtitle=AIDS%20research%20and%20human%20retroviruses&rft.au=ANASTASSOPOULOU,%20Cleo%20G&rft.date=2003&rft.volume=19&rft.issue=1&rft.spage=65&rft.epage=71&rft.pages=65-71&rft.issn=0889-2229&rft.eissn=1931-8405&rft.coden=ARHRE7&rft_id=info:doi/10.1089/08892220360473989&rft_dat=%3Cproquest_cross%3E18717396%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18717396&rft_id=info:pmid/12596725&rfr_iscdi=true |