Relationship between self-association of insulin and its secretion efficiency in yeast

The folding stability of insulin is positively correlated with the expression yield of the precursor expressed in yeast. Insulin assembles into dimers and hexamers in a concentration-dependent manner and amino acid substitutions that impair the ability of insulin to associate into dimers concomitant...

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Veröffentlicht in:	Protein expression and purification 2003-02, Vol.27 (2), p.331-337
Hauptverfasser:	Kjeldsen, Thomas, Pettersson, Annette Frost
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Dimerization Hydrogen-Ion Concentration Insulin - chemistry Insulin - metabolism Models, Molecular Protein Folding Saccharomyces cerevisiae - metabolism Time Factors
Online-Zugang:	Volltext
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