ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer’s disease

Increased formation of the β-amyloid peptide (Aβ) is a central event in the pathogenesis of Alzheimer’s disease (AD). High cellular cholesterol load promotes Aβ formation. The ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux from cells. We hypothesized that genetic variability...

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Veröffentlicht in:	Neurobiology of aging 2003-05, Vol.24 (3), p.421-426
Hauptverfasser:	Wollmer, M.Axel, Streffer, Johannes R, Lütjohann, Dieter, Tsolaki, Magdalini, Iakovidou, Vassiliki, Hegi, Thomas, Pasch, Thomas, Jung, Hans H, Bergmann, Klaus von, Nitsch, Roger M, Hock, Christoph, Papassotiropoulos, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Alzheimer Disease - epidemiology Alzheimer Disease - genetics Amyloid beta-Peptides - analysis Amyloid beta-Peptides - genetics ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - genetics Biological and medical sciences Case-Control Studies Cholesterol - cerebrospinal fluid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Genetic association Greece - epidemiology Humans Male Medical sciences Middle Aged Neurology Polymorphism, Genetic Risk Factors Single nucleotide polymorphism Switzerland - epidemiology β-Amyloid
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