Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease

Oxygen consumption and enzyme activity were evaluted in platelet mitochondria from 17 patients with Parkinson's disease. In comparison with age‐matched controls, no consistent abnormality could be discerned in complex I, complex II‐III, or complex IV oxygen consumption, or in the enzyme activit...

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Veröffentlicht in:	Movement disorders 1992, Vol.7 (3), p.228-231
Hauptverfasser:	Bravi, Daniele, Anderson, Jeffrey J., Dagani, Fiorenzo, Davis, Thomas L., Ferrari, Rosaria, Gillespie, Marge, Chase, Thomas N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Biological and medical sciences Blood Glucose - metabolism Blood Platelets - drug effects Blood Platelets - physiology Carbidopa - administration & dosage Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug Therapy, Combination Energy Metabolism - drug effects Energy Metabolism - physiology Female Glucose Humans Lactate Lactates - blood Lactic Acid Levodopa - administration & dosage Lisuride - administration & dosage Male Medical sciences Middle Aged Mitochondria Mitochondria - drug effects Mitochondria - physiology Neurology Oxygen Consumption - drug effects Oxygen Consumption - physiology Parkinson Disease - drug therapy Parkinson Disease - physiopathology Platelets Receptors, Dopamine - drug effects Receptors, Dopamine - physiology Respiration Selegiline - administration & dosage
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