Properties of Rapidly Dissolving Eutectic Mixtures of Poly(ethylene glycol) and Fenofibrate:The Eutectic Microstructure

Poly(ethylene glycol) or PEG is an ideal inactive component for preparing simple binary eutectic mixtures because of its low entropy of fusion (∼0.0076 J/mol‐K), lower melting point (∼62°C) compared to most pharmaceuticals, miscibility with drugs at elevated temperatures, and its covalent crystallin...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2003-03, Vol.92 (3), p.505-515
Hauptverfasser:	Law, Devalina, Wang, Weili, Schmitt, Eric A., Qiu, Yihong, Krill, Steven L., Fort, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry, Pharmaceutical Drug Carriers - chemistry Drug Carriers - pharmacokinetics eutectic eutectic microstructure fenofibrate Fenofibrate - chemistry Fenofibrate - pharmacokinetics General and cellular metabolism. Vitamins Medical sciences Microspheres Pharmacology. Drug treatments poly(ethylene glycol) Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics solid dispersion Solubility
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