The Yaa Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells

The accelerated development of systemic lupus erythematosus (SLE) in BXSB male mice is associated with the presence of an as yet unidentified mutant gene, Yaa (Y-linked autoimmune acceleration). In view of a possible role of marginal zone (MZ) B cells in murine SLE, we have explored whether the expr...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-03, Vol.170 (5), p.2293-2301
Hauptverfasser:	Amano, Hirofumi, Amano, Eri, Moll, Thomas, Marinkovic, Dragan, Ibnou-Zekri, Nabila, Martinez-Soria, Eduardo, Semac, Isabelle, Wirth, Thomas, Nitschke, Lars, Izui, Shozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, T-Independent - administration & dosage Antigens, T-Independent - immunology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism B-Lymphocyte Subsets - pathology Cell Differentiation - genetics Cell Differentiation - immunology Cells, Cultured Down-Regulation - genetics Down-Regulation - immunology Gene Expression Regulation - immunology Immunoglobulin M - biosynthesis Immunoglobulin M - genetics Injections, Intravenous Kruppel-Like Transcription Factors Lupus Nephritis - genetics Lupus Nephritis - immunology Lupus Nephritis - pathology Lymphocyte Count Lymphopenia - genetics Lymphopenia - immunology Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Mice, Transgenic Mutation Receptors, Complement 3d - biosynthesis Spleen - immunology Spleen - metabolism Spleen - pathology Stem Cells - immunology Stem Cells - pathology Transcription Factors - biosynthesis Transcription Factors - deficiency Transcription Factors - genetics Transgenes - immunology Trinitrobenzenes - immunology Y Chromosome - genetics Y Chromosome - immunology
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