Long-term survival and cause-specific mortality in patients with cirrhosis of the liver: a nationwide cohort study in Denmark
Mortality from cirrhosis of the liver has been examined in few long-term follow-up studies. In the Danish National Registry of Patients, 1982–1989, we identified a cohort of 10,154 patients with liver cirrhosis and divided them according to the etiology of their liver disease. Causes of death were i...
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| Veröffentlicht in: | Journal of clinical epidemiology 2003, Vol.56 (1), p.88-93 |
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| creator | Sørensen, Henrik Toft Thulstrup, Ane Marie Mellemkjar, Lene Jepsen, Peter Christensen, Erik Olsen, Jørgen H Vilstrup, Hendrik |
| description | Mortality from cirrhosis of the liver has been examined in few long-term follow-up studies. In the Danish National Registry of Patients, 1982–1989, we identified a cohort of 10,154 patients with liver cirrhosis and divided them according to the etiology of their liver disease. Causes of death were identified in the Danish Death Registry, 1982–1993. We estimated relative survival and standardized mortality ratios by comparing with the mortality in the general population. The 10-year relative survival was worse in patients with alcoholic cirrhosis (34%) or nonspecified cirrhosis (32%) than in patients with primary biliary cirrhosis (58%) or chronic hepatitis (66%). The standardized mortality ratio for all causes of death combined was 12-fold increased, 5-fold excluding cirrhosis-related causes. Mortality in all disease categories was increased, even in those not traditionally related to cirrhosis. In conclusion, patients with cirrhosis of the liver face reduced life expectancy due to several causes of death. |
| doi_str_mv | 10.1016/S0895-4356(02)00531-0 |
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In the Danish National Registry of Patients, 1982–1989, we identified a cohort of 10,154 patients with liver cirrhosis and divided them according to the etiology of their liver disease. Causes of death were identified in the Danish Death Registry, 1982–1993. We estimated relative survival and standardized mortality ratios by comparing with the mortality in the general population. The 10-year relative survival was worse in patients with alcoholic cirrhosis (34%) or nonspecified cirrhosis (32%) than in patients with primary biliary cirrhosis (58%) or chronic hepatitis (66%). The standardized mortality ratio for all causes of death combined was 12-fold increased, 5-fold excluding cirrhosis-related causes. Mortality in all disease categories was increased, even in those not traditionally related to cirrhosis. In conclusion, patients with cirrhosis of the liver face reduced life expectancy due to several causes of death.</description><identifier>ISSN: 0895-4356</identifier><identifier>EISSN: 1878-5921</identifier><identifier>DOI: 10.1016/S0895-4356(02)00531-0</identifier><identifier>PMID: 12589875</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cardiovascular disease ; Cause of Death ; Cause-specific ; Cohort Studies ; Denmark - epidemiology ; Endocrine disorders ; Epidemiology ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis ; Humans ; Life expectancy ; Liver ; Liver cirrhosis ; Liver Cirrhosis - mortality ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Mortality ; Other diseases. Semiology ; Prognosis ; Respiratory system ; Risk Factors ; Survival ; Survival Analysis ; Tumors</subject><ispartof>Journal of clinical epidemiology, 2003, Vol.56 (1), p.88-93</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0895435602005310$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14580462$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12589875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sørensen, Henrik Toft</creatorcontrib><creatorcontrib>Thulstrup, Ane Marie</creatorcontrib><creatorcontrib>Mellemkjar, Lene</creatorcontrib><creatorcontrib>Jepsen, Peter</creatorcontrib><creatorcontrib>Christensen, Erik</creatorcontrib><creatorcontrib>Olsen, Jørgen H</creatorcontrib><creatorcontrib>Vilstrup, Hendrik</creatorcontrib><title>Long-term survival and cause-specific mortality in patients with cirrhosis of the liver: a nationwide cohort study in Denmark</title><title>Journal of clinical epidemiology</title><addtitle>J Clin Epidemiol</addtitle><description>Mortality from cirrhosis of the liver has been examined in few long-term follow-up studies. In the Danish National Registry of Patients, 1982–1989, we identified a cohort of 10,154 patients with liver cirrhosis and divided them according to the etiology of their liver disease. Causes of death were identified in the Danish Death Registry, 1982–1993. We estimated relative survival and standardized mortality ratios by comparing with the mortality in the general population. The 10-year relative survival was worse in patients with alcoholic cirrhosis (34%) or nonspecified cirrhosis (32%) than in patients with primary biliary cirrhosis (58%) or chronic hepatitis (66%). The standardized mortality ratio for all causes of death combined was 12-fold increased, 5-fold excluding cirrhosis-related causes. Mortality in all disease categories was increased, even in those not traditionally related to cirrhosis. In conclusion, patients with cirrhosis of the liver face reduced life expectancy due to several causes of death.</description><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Cause of Death</subject><subject>Cause-specific</subject><subject>Cohort Studies</subject><subject>Denmark - epidemiology</subject><subject>Endocrine disorders</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Life expectancy</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - mortality</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Other diseases. 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Liver. Pancreas. Abdomen</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Life expectancy</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - mortality</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Other diseases. 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In the Danish National Registry of Patients, 1982–1989, we identified a cohort of 10,154 patients with liver cirrhosis and divided them according to the etiology of their liver disease. Causes of death were identified in the Danish Death Registry, 1982–1993. We estimated relative survival and standardized mortality ratios by comparing with the mortality in the general population. The 10-year relative survival was worse in patients with alcoholic cirrhosis (34%) or nonspecified cirrhosis (32%) than in patients with primary biliary cirrhosis (58%) or chronic hepatitis (66%). The standardized mortality ratio for all causes of death combined was 12-fold increased, 5-fold excluding cirrhosis-related causes. Mortality in all disease categories was increased, even in those not traditionally related to cirrhosis. In conclusion, patients with cirrhosis of the liver face reduced life expectancy due to several causes of death.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12589875</pmid><doi>10.1016/S0895-4356(02)00531-0</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of clinical epidemiology, 2003, Vol.56 (1), p.88-93 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Cardiovascular disease Cause of Death Cause-specific Cohort Studies Denmark - epidemiology Endocrine disorders Epidemiology Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Hepatitis Humans Life expectancy Liver Liver cirrhosis Liver Cirrhosis - mortality Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Mortality Other diseases. Semiology Prognosis Respiratory system Risk Factors Survival Survival Analysis Tumors |
| title | Long-term survival and cause-specific mortality in patients with cirrhosis of the liver: a nationwide cohort study in Denmark |
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