Double Immunolabeling by the RBM and the PLAP Markers for Identifying Intratubular (in Situ) Germ Cell Neoplasia of the Testis
Identification of intratubular germ cell neoplasia (carcinoma in situ, CIS) of the testis is a diagnostic challenge, and markers are sorely needed to assist in accurately identifying the lesion. RNA-binding motif (RBM) protein, encoded by the Y chromosome, is expressed exclusively and consistently i...
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| Veröffentlicht in: | International journal of surgical pathology 2003-01, Vol.11 (1), p.17-20 |
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| creator | Schreiber, Letizia Lifschitz-Mercer, Beatriz Paz, Gedalia Yavetz, Haim Elliott, David J. Kula, Krzysztof Slowikowska-Hilczer, Jolanta Maymon, Batia Bar-Shira |
| description | Identification of intratubular germ cell neoplasia (carcinoma in situ, CIS) of the testis is a diagnostic challenge, and markers are sorely needed to assist in accurately identifying the lesion. RNA-binding motif (RBM) protein, encoded by the Y chromosome, is expressed exclusively and consistently in differentiated male germ cells, while it is absent in neoplastic germ cells. Another immunohistochemical marker, placental alkaline phosphatase (PLAP), is commonly used for the detection of undifferentiated germ cells. The current study demonstrates that simultaneous use of the immunohistochemical markers, RBM and PLAP, by double immunolabeling enhances the accuracy of diagnosing CIS, a preinvasive testicular neoplasm. |
| doi_str_mv | 10.1177/106689690301100104 |
| format | Article |
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RNA-binding motif (RBM) protein, encoded by the Y chromosome, is expressed exclusively and consistently in differentiated male germ cells, while it is absent in neoplastic germ cells. Another immunohistochemical marker, placental alkaline phosphatase (PLAP), is commonly used for the detection of undifferentiated germ cells. The current study demonstrates that simultaneous use of the immunohistochemical markers, RBM and PLAP, by double immunolabeling enhances the accuracy of diagnosing CIS, a preinvasive testicular neoplasm.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/106689690301100104</identifier><identifier>PMID: 12598912</identifier><identifier>CODEN: IJSPFL</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Alkaline Phosphatase ; Biomarkers, Tumor - analysis ; Cancer ; Carcinoma in situ ; Carcinoma in Situ - chemistry ; Carcinoma in Situ - pathology ; Child, Preschool ; Diagnosis ; Fluorescent Antibody Technique, Indirect ; Germinoma - chemistry ; Germinoma - pathology ; GPI-Linked Proteins ; Humans ; Immunoenzyme Techniques ; Isoenzymes - analysis ; Male ; Neoplastic processes ; Physiological aspects ; RNA-Binding Proteins - analysis ; Testicular Neoplasms - chemistry ; Testicular Neoplasms - pathology ; Testis</subject><ispartof>International journal of surgical pathology, 2003-01, Vol.11 (1), p.17-20</ispartof><rights>COPYRIGHT 2003 Sage Publications, Inc.</rights><rights>Copyright Westminster Publications, Inc. 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RNA-binding motif (RBM) protein, encoded by the Y chromosome, is expressed exclusively and consistently in differentiated male germ cells, while it is absent in neoplastic germ cells. Another immunohistochemical marker, placental alkaline phosphatase (PLAP), is commonly used for the detection of undifferentiated germ cells. The current study demonstrates that simultaneous use of the immunohistochemical markers, RBM and PLAP, by double immunolabeling enhances the accuracy of diagnosing CIS, a preinvasive testicular neoplasm.</description><subject>Alkaline Phosphatase</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cancer</subject><subject>Carcinoma in situ</subject><subject>Carcinoma in Situ - chemistry</subject><subject>Carcinoma in Situ - pathology</subject><subject>Child, Preschool</subject><subject>Diagnosis</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Germinoma - chemistry</subject><subject>Germinoma - pathology</subject><subject>GPI-Linked Proteins</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Isoenzymes - analysis</subject><subject>Male</subject><subject>Neoplastic processes</subject><subject>Physiological aspects</subject><subject>RNA-Binding Proteins - analysis</subject><subject>Testicular Neoplasms - chemistry</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testis</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1vEzEQhlcIREvLH-CALA4VldjW9n76GEJbIqVQQTmvxt5xcPHawd495MJvr9NEqgQVGkseWc-8844ny94wesZY05wzWtetqAUtKGOUMlo-yw6ZKGnOy7p6nvIE5FviIHsV4x2llNecvcwOGK9EKxg_zP588pO0SBbDMDlvQaI1bkXkhow_kXz7eE3A9Q_5zXJ2Q64h_MIQifaBLHp0o9GbLb9wY4BxkpOFQN4bR76bcTolVxgGMkdryRf0awvRAPH6Qe4W42jicfZCg434en8fZT8uL27nn_Pl16vFfLbMVVmyMVeyUbxVleS9RCkkBS5ByKIuGWOiklVdQyu0Rq0AWM_Tl_RtCqoq4L1uiqPsZKe7Dv73lFp3g4kqGQOHfopdU9AinTaB7_4C7_wUXPLWcVamXrQpEvRhB63AYmec9ml6tUKHAax3qE16nomWt7QSVcLzJ_AUPQ5GPcXzHa-CjzGg7tbBDBA2HaPddvPdv5tPRW_3xic5YP9Ysl91As53QIQVPk71H8l7Sg-1Mw</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Schreiber, Letizia</creator><creator>Lifschitz-Mercer, Beatriz</creator><creator>Paz, Gedalia</creator><creator>Yavetz, Haim</creator><creator>Elliott, David J.</creator><creator>Kula, Krzysztof</creator><creator>Slowikowska-Hilczer, Jolanta</creator><creator>Maymon, Batia Bar-Shira</creator><general>SAGE Publications</general><general>Sage Publications, Inc</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>Double Immunolabeling by the RBM and the PLAP Markers for Identifying Intratubular (in Situ) Germ Cell Neoplasia of the Testis</title><author>Schreiber, Letizia ; Lifschitz-Mercer, Beatriz ; Paz, Gedalia ; Yavetz, Haim ; Elliott, David J. ; Kula, Krzysztof ; Slowikowska-Hilczer, Jolanta ; Maymon, Batia Bar-Shira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-cb7c28c5b2dbeb9b0a2ba9b36411195b566a89ffefcaa1d2903d8d8d0c5a2df73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alkaline Phosphatase</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Cancer</topic><topic>Carcinoma in situ</topic><topic>Carcinoma in Situ - chemistry</topic><topic>Carcinoma in Situ - pathology</topic><topic>Child, Preschool</topic><topic>Diagnosis</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Germinoma - chemistry</topic><topic>Germinoma - pathology</topic><topic>GPI-Linked Proteins</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Isoenzymes - analysis</topic><topic>Male</topic><topic>Neoplastic processes</topic><topic>Physiological aspects</topic><topic>RNA-Binding Proteins - analysis</topic><topic>Testicular Neoplasms - chemistry</topic><topic>Testicular Neoplasms - pathology</topic><topic>Testis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schreiber, Letizia</creatorcontrib><creatorcontrib>Lifschitz-Mercer, Beatriz</creatorcontrib><creatorcontrib>Paz, Gedalia</creatorcontrib><creatorcontrib>Yavetz, Haim</creatorcontrib><creatorcontrib>Elliott, David J.</creatorcontrib><creatorcontrib>Kula, Krzysztof</creatorcontrib><creatorcontrib>Slowikowska-Hilczer, Jolanta</creatorcontrib><creatorcontrib>Maymon, Batia Bar-Shira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schreiber, Letizia</au><au>Lifschitz-Mercer, Beatriz</au><au>Paz, Gedalia</au><au>Yavetz, Haim</au><au>Elliott, David J.</au><au>Kula, Krzysztof</au><au>Slowikowska-Hilczer, Jolanta</au><au>Maymon, Batia Bar-Shira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Double Immunolabeling by the RBM and the PLAP Markers for Identifying Intratubular (in Situ) Germ Cell Neoplasia of the Testis</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2003-01</date><risdate>2003</risdate><volume>11</volume><issue>1</issue><spage>17</spage><epage>20</epage><pages>17-20</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><coden>IJSPFL</coden><abstract>Identification of intratubular germ cell neoplasia (carcinoma in situ, CIS) of the testis is a diagnostic challenge, and markers are sorely needed to assist in accurately identifying the lesion. RNA-binding motif (RBM) protein, encoded by the Y chromosome, is expressed exclusively and consistently in differentiated male germ cells, while it is absent in neoplastic germ cells. Another immunohistochemical marker, placental alkaline phosphatase (PLAP), is commonly used for the detection of undifferentiated germ cells. The current study demonstrates that simultaneous use of the immunohistochemical markers, RBM and PLAP, by double immunolabeling enhances the accuracy of diagnosing CIS, a preinvasive testicular neoplasm.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>12598912</pmid><doi>10.1177/106689690301100104</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1066-8969 |
| ispartof | International journal of surgical pathology, 2003-01, Vol.11 (1), p.17-20 |
| issn | 1066-8969 1940-2465 |
| language | eng |
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| source | SAGE Complete A-Z List; MEDLINE |
| subjects | Alkaline Phosphatase Biomarkers, Tumor - analysis Cancer Carcinoma in situ Carcinoma in Situ - chemistry Carcinoma in Situ - pathology Child, Preschool Diagnosis Fluorescent Antibody Technique, Indirect Germinoma - chemistry Germinoma - pathology GPI-Linked Proteins Humans Immunoenzyme Techniques Isoenzymes - analysis Male Neoplastic processes Physiological aspects RNA-Binding Proteins - analysis Testicular Neoplasms - chemistry Testicular Neoplasms - pathology Testis |
| title | Double Immunolabeling by the RBM and the PLAP Markers for Identifying Intratubular (in Situ) Germ Cell Neoplasia of the Testis |
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