Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation
In an animal model, stretch was shown to induce myocardial tumor necrosis factor-alpha (TNF-alpha) expression. The purposes of this study were to determine whether the left ventricular (LV) volume overload that occurs in patients with chronic mitral regurgitation (MR) can induce myocardial and syste...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2003-02, Vol.107 (6), p.831-837 |
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| creator | ORAL, Hakan SIVASUBRAMANIAN, Natarajan STARLING, Mark R DYKE, David B MEHTA, Rajendra H GROSSMAN, P. Michael BRIESMIESTER, Kerri FAY, William P PAGANI, Francis D BOILING, Steven F MANN, Douglas L |
| description | In an animal model, stretch was shown to induce myocardial tumor necrosis factor-alpha (TNF-alpha) expression. The purposes of this study were to determine whether the left ventricular (LV) volume overload that occurs in patients with chronic mitral regurgitation (MR) can induce myocardial and systemic TNF-alpha expression and whether there is a relationship between TNF-alpha expression and LV remodeling.
Plasma TNF-alpha and its receptors were measured before mitral valve (MV) repair surgery in 26 MR patients and 23+/-12 months after MV repair surgery in 9 MR patients. Myocardial mRNA copies of TNF-alpha were determined in 11 MR and 10 donor hearts using quantitative RT-PCR. Compared with 15 control subjects, pre-MV repair plasma TNF-alpha (3.59+/-1.81 versus 2.03+/-1.02 pg/mL, P |
| doi_str_mv | 10.1161/01.CIR.0000049745.38594.6D |
| format | Article |
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Plasma TNF-alpha and its receptors were measured before mitral valve (MV) repair surgery in 26 MR patients and 23+/-12 months after MV repair surgery in 9 MR patients. Myocardial mRNA copies of TNF-alpha were determined in 11 MR and 10 donor hearts using quantitative RT-PCR. Compared with 15 control subjects, pre-MV repair plasma TNF-alpha (3.59+/-1.81 versus 2.03+/-1.02 pg/mL, P<0.005) and its receptor levels were elevated in MR patients. Myocardial TNF-alpha mRNA copies (corrected for beta-actin mRNA expression) in MR patients and donor hearts were 38.96+/-42.74x10(6) and 0.88+/-0.75x10(6), respectively (P=0.01). After MV surgery, there was a decrease in the plasma levels of TNF-alpha (2.79+/-1.14 versus 3.51+/-1.34 pg/mL, P=0.02) and its receptors. There was a correlation between myocardial TNF-alpha expression and preoperative LV end-diastolic and end-systolic volumes. Moreover, there was an inverse correlation between myocardial TNF-alpha expression and regression in LV end-diastolic (r=-0.76, P=0.007) and end-systolic (r=-0.73, P=0.01) volumes after MV surgery.
TNF-alpha is expressed in the myocardium and plasma of MR patients. Correction of the LV volume overload with MV surgery results in reversal of TNF-alpha expression. There is a relationship between TNF-alpha expression and parameters of LV remodeling, suggesting that TNF-alpha may play a role in the pathogenesis of the LV remodeling that occurs in MR.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000049745.38594.6D</identifier><identifier>PMID: 12591752</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Antigens, CD - blood ; Biological and medical sciences ; Biopsy ; Chronic Disease ; Cytokines - analysis ; Cytokines - genetics ; Cytokines - metabolism ; Female ; Hemodynamics ; Humans ; Interleukin-6 - blood ; Male ; Medical sciences ; Middle Aged ; Mitral Valve - surgery ; Mitral Valve Insufficiency - physiopathology ; Mitral Valve Insufficiency - surgery ; Myocardium - chemistry ; Myocardium - metabolism ; Postoperative Period ; Receptors, Interleukin-6 - blood ; Receptors, Tumor Necrosis Factor - blood ; Receptors, Tumor Necrosis Factor, Type I ; Receptors, Tumor Necrosis Factor, Type II ; Reference Values ; RNA, Messenger - metabolism ; Severity of Illness Index ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Tumor Necrosis Factor-alpha - analysis ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism ; Ventricular Remodeling</subject><ispartof>Circulation (New York, N.Y.), 2003-02, Vol.107 (6), p.831-837</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Feb 18 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-e6d3a941a0e58e2df73c014bf4bec2688aa545ed1ce6d19de2eae1ffea60b67a3</citedby><cites>FETCH-LOGICAL-c522t-e6d3a941a0e58e2df73c014bf4bec2688aa545ed1ce6d19de2eae1ffea60b67a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14562584$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12591752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ORAL, Hakan</creatorcontrib><creatorcontrib>SIVASUBRAMANIAN, Natarajan</creatorcontrib><creatorcontrib>STARLING, Mark R</creatorcontrib><creatorcontrib>DYKE, David B</creatorcontrib><creatorcontrib>MEHTA, Rajendra H</creatorcontrib><creatorcontrib>GROSSMAN, P. Michael</creatorcontrib><creatorcontrib>BRIESMIESTER, Kerri</creatorcontrib><creatorcontrib>FAY, William P</creatorcontrib><creatorcontrib>PAGANI, Francis D</creatorcontrib><creatorcontrib>BOILING, Steven F</creatorcontrib><creatorcontrib>MANN, Douglas L</creatorcontrib><title>Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>In an animal model, stretch was shown to induce myocardial tumor necrosis factor-alpha (TNF-alpha) expression. The purposes of this study were to determine whether the left ventricular (LV) volume overload that occurs in patients with chronic mitral regurgitation (MR) can induce myocardial and systemic TNF-alpha expression and whether there is a relationship between TNF-alpha expression and LV remodeling.
Plasma TNF-alpha and its receptors were measured before mitral valve (MV) repair surgery in 26 MR patients and 23+/-12 months after MV repair surgery in 9 MR patients. Myocardial mRNA copies of TNF-alpha were determined in 11 MR and 10 donor hearts using quantitative RT-PCR. Compared with 15 control subjects, pre-MV repair plasma TNF-alpha (3.59+/-1.81 versus 2.03+/-1.02 pg/mL, P<0.005) and its receptor levels were elevated in MR patients. Myocardial TNF-alpha mRNA copies (corrected for beta-actin mRNA expression) in MR patients and donor hearts were 38.96+/-42.74x10(6) and 0.88+/-0.75x10(6), respectively (P=0.01). After MV surgery, there was a decrease in the plasma levels of TNF-alpha (2.79+/-1.14 versus 3.51+/-1.34 pg/mL, P=0.02) and its receptors. There was a correlation between myocardial TNF-alpha expression and preoperative LV end-diastolic and end-systolic volumes. Moreover, there was an inverse correlation between myocardial TNF-alpha expression and regression in LV end-diastolic (r=-0.76, P=0.007) and end-systolic (r=-0.73, P=0.01) volumes after MV surgery.
TNF-alpha is expressed in the myocardium and plasma of MR patients. Correction of the LV volume overload with MV surgery results in reversal of TNF-alpha expression. There is a relationship between TNF-alpha expression and parameters of LV remodeling, suggesting that TNF-alpha may play a role in the pathogenesis of the LV remodeling that occurs in MR.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, CD - blood</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Chronic Disease</subject><subject>Cytokines - analysis</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Female</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitral Valve - surgery</subject><subject>Mitral Valve Insufficiency - physiopathology</subject><subject>Mitral Valve Insufficiency - surgery</subject><subject>Myocardium - chemistry</subject><subject>Myocardium - metabolism</subject><subject>Postoperative Period</subject><subject>Receptors, Interleukin-6 - blood</subject><subject>Receptors, Tumor Necrosis Factor - blood</subject><subject>Receptors, Tumor Necrosis Factor, Type I</subject><subject>Receptors, Tumor Necrosis Factor, Type II</subject><subject>Reference Values</subject><subject>RNA, Messenger - metabolism</subject><subject>Severity of Illness Index</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Ventricular Remodeling</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkW1rFDEQgIMo9qz-BQkF_bZn3nfXb3L1pVARRD-HuezsNXU3OZNs9cAfb2oPDpwvwzDPzCQ8hFxwtubc8DeMrzdXX9fsPlTfKr2Wne7V2lw-IiuuhWqUlv1jsqr9vmmlEGfkWc63tTSy1U_JGRe6560WK_Ln8yE6SIOHie5T9GGcYJ6hxHSg7lDiDx-Q4u99wpx9DBTCQCccC73DUJJ3ywSJJpzjgJMPO-oD3UPxtZnpL19uqLtJMXhHZ19SvZFwt6SdL5WJ4Tl5MsKU8cUxn5PvH95_23xqrr98vNq8u26cFqI0aAYJveLAUHcohrGVjnG1HdUWnTBdB6CVxoG7SvJ-QIGAfBwRDNuaFuQ5ef2wt_7w54K52Nlnh9MEAeOSbSuZlEyoCl78B97GJYX6Niu4MKYzWlfo7QPkUsw54Wj3yc-QDpYzey_IMm6rIHsSZP8JsuayDr88Xli2Mw6n0aORCrw6ApAdTGOC4Hw-cUoboTsl_wJ6-537</recordid><startdate>20030218</startdate><enddate>20030218</enddate><creator>ORAL, Hakan</creator><creator>SIVASUBRAMANIAN, Natarajan</creator><creator>STARLING, Mark R</creator><creator>DYKE, David B</creator><creator>MEHTA, Rajendra H</creator><creator>GROSSMAN, P. Michael</creator><creator>BRIESMIESTER, Kerri</creator><creator>FAY, William P</creator><creator>PAGANI, Francis D</creator><creator>BOILING, Steven F</creator><creator>MANN, Douglas L</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20030218</creationdate><title>Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation</title><author>ORAL, Hakan ; SIVASUBRAMANIAN, Natarajan ; STARLING, Mark R ; DYKE, David B ; MEHTA, Rajendra H ; GROSSMAN, P. Michael ; BRIESMIESTER, Kerri ; FAY, William P ; PAGANI, Francis D ; BOILING, Steven F ; MANN, Douglas L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-e6d3a941a0e58e2df73c014bf4bec2688aa545ed1ce6d19de2eae1ffea60b67a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, CD - blood</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Chronic Disease</topic><topic>Cytokines - analysis</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Female</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitral Valve - surgery</topic><topic>Mitral Valve Insufficiency - physiopathology</topic><topic>Mitral Valve Insufficiency - surgery</topic><topic>Myocardium - chemistry</topic><topic>Myocardium - metabolism</topic><topic>Postoperative Period</topic><topic>Receptors, Interleukin-6 - blood</topic><topic>Receptors, Tumor Necrosis Factor - blood</topic><topic>Receptors, Tumor Necrosis Factor, Type I</topic><topic>Receptors, Tumor Necrosis Factor, Type II</topic><topic>Reference Values</topic><topic>RNA, Messenger - metabolism</topic><topic>Severity of Illness Index</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ORAL, Hakan</creatorcontrib><creatorcontrib>SIVASUBRAMANIAN, Natarajan</creatorcontrib><creatorcontrib>STARLING, Mark R</creatorcontrib><creatorcontrib>DYKE, David B</creatorcontrib><creatorcontrib>MEHTA, Rajendra H</creatorcontrib><creatorcontrib>GROSSMAN, P. Michael</creatorcontrib><creatorcontrib>BRIESMIESTER, Kerri</creatorcontrib><creatorcontrib>FAY, William P</creatorcontrib><creatorcontrib>PAGANI, Francis D</creatorcontrib><creatorcontrib>BOILING, Steven F</creatorcontrib><creatorcontrib>MANN, Douglas L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ORAL, Hakan</au><au>SIVASUBRAMANIAN, Natarajan</au><au>STARLING, Mark R</au><au>DYKE, David B</au><au>MEHTA, Rajendra H</au><au>GROSSMAN, P. Michael</au><au>BRIESMIESTER, Kerri</au><au>FAY, William P</au><au>PAGANI, Francis D</au><au>BOILING, Steven F</au><au>MANN, Douglas L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2003-02-18</date><risdate>2003</risdate><volume>107</volume><issue>6</issue><spage>831</spage><epage>837</epage><pages>831-837</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>In an animal model, stretch was shown to induce myocardial tumor necrosis factor-alpha (TNF-alpha) expression. The purposes of this study were to determine whether the left ventricular (LV) volume overload that occurs in patients with chronic mitral regurgitation (MR) can induce myocardial and systemic TNF-alpha expression and whether there is a relationship between TNF-alpha expression and LV remodeling.
Plasma TNF-alpha and its receptors were measured before mitral valve (MV) repair surgery in 26 MR patients and 23+/-12 months after MV repair surgery in 9 MR patients. Myocardial mRNA copies of TNF-alpha were determined in 11 MR and 10 donor hearts using quantitative RT-PCR. Compared with 15 control subjects, pre-MV repair plasma TNF-alpha (3.59+/-1.81 versus 2.03+/-1.02 pg/mL, P<0.005) and its receptor levels were elevated in MR patients. Myocardial TNF-alpha mRNA copies (corrected for beta-actin mRNA expression) in MR patients and donor hearts were 38.96+/-42.74x10(6) and 0.88+/-0.75x10(6), respectively (P=0.01). After MV surgery, there was a decrease in the plasma levels of TNF-alpha (2.79+/-1.14 versus 3.51+/-1.34 pg/mL, P=0.02) and its receptors. There was a correlation between myocardial TNF-alpha expression and preoperative LV end-diastolic and end-systolic volumes. Moreover, there was an inverse correlation between myocardial TNF-alpha expression and regression in LV end-diastolic (r=-0.76, P=0.007) and end-systolic (r=-0.73, P=0.01) volumes after MV surgery.
TNF-alpha is expressed in the myocardium and plasma of MR patients. Correction of the LV volume overload with MV surgery results in reversal of TNF-alpha expression. There is a relationship between TNF-alpha expression and parameters of LV remodeling, suggesting that TNF-alpha may play a role in the pathogenesis of the LV remodeling that occurs in MR.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12591752</pmid><doi>10.1161/01.CIR.0000049745.38594.6D</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 2003-02, Vol.107 (6), p.831-837 |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Antigens, CD - blood Biological and medical sciences Biopsy Chronic Disease Cytokines - analysis Cytokines - genetics Cytokines - metabolism Female Hemodynamics Humans Interleukin-6 - blood Male Medical sciences Middle Aged Mitral Valve - surgery Mitral Valve Insufficiency - physiopathology Mitral Valve Insufficiency - surgery Myocardium - chemistry Myocardium - metabolism Postoperative Period Receptors, Interleukin-6 - blood Receptors, Tumor Necrosis Factor - blood Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Reference Values RNA, Messenger - metabolism Severity of Illness Index Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Ventricular Remodeling |
| title | Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation |
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