Paecilomyces variotii central nervous system infection in a patient with cancer
Summary Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through β‐tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B...
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| Veröffentlicht in: | Mycoses 2003-02, Vol.46 (1‐2), p.45-50 |
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| creator | Kantarcıoğlu, A. S. Hatemi, G. Yücel, A. De Hoog, G. S. Mandel, N. M. |
| description | Summary
Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through β‐tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5‐fluorocytosine (5FC) but resistant to fluconazole (FLZ) and miconazole (MCZ). Despite antimycotic therapy, the infection proved to be fatal.
Zusammenfassung
Paecilomyces variotii wurde zweimal aus Liquorproben einer Krebspatientin isoliert. Die Bestimmung wurde bestätigt anhand von β‐Tubulin und rDNA‐ITS‐Sequenzierung. MHKs wurden festgestellt gegen sieben Antimykotika; das Isolat war empfindlich für Amphotericin B (AMB), Itraconazol (ITZ), Ketaconazol (KTZ) und 5‐Fluorocytosin (5FC), aber resistent gegen Fluconazol (FLZ) und Miconazol (MCZ). Trotz antimykotischer Therapie verstarb die Patientin an dieser Infektion. |
| doi_str_mv | 10.1046/j.1439-0507.2003.00837.x |
| format | Article |
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Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through β‐tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5‐fluorocytosine (5FC) but resistant to fluconazole (FLZ) and miconazole (MCZ). Despite antimycotic therapy, the infection proved to be fatal.
Zusammenfassung
Paecilomyces variotii wurde zweimal aus Liquorproben einer Krebspatientin isoliert. Die Bestimmung wurde bestätigt anhand von β‐Tubulin und rDNA‐ITS‐Sequenzierung. MHKs wurden festgestellt gegen sieben Antimykotika; das Isolat war empfindlich für Amphotericin B (AMB), Itraconazol (ITZ), Ketaconazol (KTZ) und 5‐Fluorocytosin (5FC), aber resistent gegen Fluconazol (FLZ) und Miconazol (MCZ). Trotz antimykotischer Therapie verstarb die Patientin an dieser Infektion.</description><identifier>ISSN: 0933-7407</identifier><identifier>EISSN: 1439-0507</identifier><identifier>DOI: 10.1046/j.1439-0507.2003.00837.x</identifier><identifier>PMID: 12588483</identifier><language>eng</language><publisher>Berlin, Germany: Blackwell Verlag GmbH</publisher><subject>Antifungal Agents - pharmacology ; Antifungal Agents - therapeutic use ; Breast Neoplasms - complications ; Central Nervous System Infections - drug therapy ; Central Nervous System Infections - etiology ; cerebrospinal fluid ; Cerebrospinal Fluid - microbiology ; Female ; Humans ; Liquor ; Microbial Sensitivity Tests ; Middle Aged ; Mycoses - drug therapy ; Mycoses - etiology ; Opportunist ; Opportunistic Infections ; Paecilomyces - drug effects ; Paecilomyces - genetics ; Paecilomyces - isolation & purification ; Paecilomyces variotii ; systemic infection ; systemische Infektion ; Triazoles - pharmacology ; Triazoles - therapeutic use</subject><ispartof>Mycoses, 2003-02, Vol.46 (1‐2), p.45-50</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3957-e4586b575ecbf85a5fb913c0409770c98866536dd90b401d3cd5f9a037319bcf3</citedby><cites>FETCH-LOGICAL-c3957-e4586b575ecbf85a5fb913c0409770c98866536dd90b401d3cd5f9a037319bcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1439-0507.2003.00837.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1439-0507.2003.00837.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12588483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kantarcıoğlu, A. S.</creatorcontrib><creatorcontrib>Hatemi, G.</creatorcontrib><creatorcontrib>Yücel, A.</creatorcontrib><creatorcontrib>De Hoog, G. S.</creatorcontrib><creatorcontrib>Mandel, N. M.</creatorcontrib><title>Paecilomyces variotii central nervous system infection in a patient with cancer</title><title>Mycoses</title><addtitle>Mycoses</addtitle><description>Summary
Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through β‐tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5‐fluorocytosine (5FC) but resistant to fluconazole (FLZ) and miconazole (MCZ). Despite antimycotic therapy, the infection proved to be fatal.
Zusammenfassung
Paecilomyces variotii wurde zweimal aus Liquorproben einer Krebspatientin isoliert. Die Bestimmung wurde bestätigt anhand von β‐Tubulin und rDNA‐ITS‐Sequenzierung. MHKs wurden festgestellt gegen sieben Antimykotika; das Isolat war empfindlich für Amphotericin B (AMB), Itraconazol (ITZ), Ketaconazol (KTZ) und 5‐Fluorocytosin (5FC), aber resistent gegen Fluconazol (FLZ) und Miconazol (MCZ). Trotz antimykotischer Therapie verstarb die Patientin an dieser Infektion.</description><subject>Antifungal Agents - pharmacology</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Breast Neoplasms - complications</subject><subject>Central Nervous System Infections - drug therapy</subject><subject>Central Nervous System Infections - etiology</subject><subject>cerebrospinal fluid</subject><subject>Cerebrospinal Fluid - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Liquor</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Mycoses - drug therapy</subject><subject>Mycoses - etiology</subject><subject>Opportunist</subject><subject>Opportunistic Infections</subject><subject>Paecilomyces - drug effects</subject><subject>Paecilomyces - genetics</subject><subject>Paecilomyces - isolation & purification</subject><subject>Paecilomyces variotii</subject><subject>systemic infection</subject><subject>systemische Infektion</subject><subject>Triazoles - pharmacology</subject><subject>Triazoles - therapeutic use</subject><issn>0933-7407</issn><issn>1439-0507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQhi0EoqXwCsgnbgnjOI5tiQuq2KSicoADJ8txHOEqS7HT7e1JaAVHOM0vzTeLPoQwgZhAml0vYpJSGQEDHicANAYQlMfbIzT-aRyjMUhKI54CH6GzEBYAhMskO0UjkjAhUkHHaP6irXFVW--MDXitvWs757CxTed1hRvr1-0q4LALna2xa0prOtc2fcIaL3XnehBvXPeBjW6M9efopNRVsBeHOkFv93ev08doNn94mt7OIkMl45FNmchyxpk1eSmYZmUuCTWQguQcjBQiyxjNikJCngIpqClYKTVQTonMTUkn6Gq_d-nbz5UNnapdMLaqdGP7hxWnQJMsIX-CRGSDCuhBsQeNb0PwtlRL72rtd4qAGqyrhRrkqkGuGqyrb-tq249eHm6s8toWv4MHzT1wswc2rrK7fy9Wz-_TPtAv7i-QcQ</recordid><startdate>200302</startdate><enddate>200302</enddate><creator>Kantarcıoğlu, A. S.</creator><creator>Hatemi, G.</creator><creator>Yücel, A.</creator><creator>De Hoog, G. S.</creator><creator>Mandel, N. M.</creator><general>Blackwell Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200302</creationdate><title>Paecilomyces variotii central nervous system infection in a patient with cancer</title><author>Kantarcıoğlu, A. S. ; Hatemi, G. ; Yücel, A. ; De Hoog, G. S. ; Mandel, N. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3957-e4586b575ecbf85a5fb913c0409770c98866536dd90b401d3cd5f9a037319bcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antifungal Agents - pharmacology</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Breast Neoplasms - complications</topic><topic>Central Nervous System Infections - drug therapy</topic><topic>Central Nervous System Infections - etiology</topic><topic>cerebrospinal fluid</topic><topic>Cerebrospinal Fluid - microbiology</topic><topic>Female</topic><topic>Humans</topic><topic>Liquor</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Mycoses - drug therapy</topic><topic>Mycoses - etiology</topic><topic>Opportunist</topic><topic>Opportunistic Infections</topic><topic>Paecilomyces - drug effects</topic><topic>Paecilomyces - genetics</topic><topic>Paecilomyces - isolation & purification</topic><topic>Paecilomyces variotii</topic><topic>systemic infection</topic><topic>systemische Infektion</topic><topic>Triazoles - pharmacology</topic><topic>Triazoles - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kantarcıoğlu, A. S.</creatorcontrib><creatorcontrib>Hatemi, G.</creatorcontrib><creatorcontrib>Yücel, A.</creatorcontrib><creatorcontrib>De Hoog, G. S.</creatorcontrib><creatorcontrib>Mandel, N. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Mycoses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kantarcıoğlu, A. S.</au><au>Hatemi, G.</au><au>Yücel, A.</au><au>De Hoog, G. S.</au><au>Mandel, N. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paecilomyces variotii central nervous system infection in a patient with cancer</atitle><jtitle>Mycoses</jtitle><addtitle>Mycoses</addtitle><date>2003-02</date><risdate>2003</risdate><volume>46</volume><issue>1‐2</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0933-7407</issn><eissn>1439-0507</eissn><abstract>Summary
Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through β‐tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5‐fluorocytosine (5FC) but resistant to fluconazole (FLZ) and miconazole (MCZ). Despite antimycotic therapy, the infection proved to be fatal.
Zusammenfassung
Paecilomyces variotii wurde zweimal aus Liquorproben einer Krebspatientin isoliert. Die Bestimmung wurde bestätigt anhand von β‐Tubulin und rDNA‐ITS‐Sequenzierung. MHKs wurden festgestellt gegen sieben Antimykotika; das Isolat war empfindlich für Amphotericin B (AMB), Itraconazol (ITZ), Ketaconazol (KTZ) und 5‐Fluorocytosin (5FC), aber resistent gegen Fluconazol (FLZ) und Miconazol (MCZ). Trotz antimykotischer Therapie verstarb die Patientin an dieser Infektion.</abstract><cop>Berlin, Germany</cop><pub>Blackwell Verlag GmbH</pub><pmid>12588483</pmid><doi>10.1046/j.1439-0507.2003.00837.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Breast Neoplasms - complications Central Nervous System Infections - drug therapy Central Nervous System Infections - etiology cerebrospinal fluid Cerebrospinal Fluid - microbiology Female Humans Liquor Microbial Sensitivity Tests Middle Aged Mycoses - drug therapy Mycoses - etiology Opportunist Opportunistic Infections Paecilomyces - drug effects Paecilomyces - genetics Paecilomyces - isolation & purification Paecilomyces variotii systemic infection systemische Infektion Triazoles - pharmacology Triazoles - therapeutic use |
| title | Paecilomyces variotii central nervous system infection in a patient with cancer |
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