Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones

The structural requirements for the gastric cytoprotective activity of several sesquiterpene lactones are reported. A theoretical-experimental study on the potentially active centers is carried out. The biological evaluation of reduced analogues and the simulation of the molecular interactions betwe...

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Veröffentlicht in:Journal of medicinal chemistry 1992-06, Vol.35 (13), p.2452-2458
Hauptverfasser: Giordano, Oscar S, Pestchanker, Mauricio J, Guerreiro, Eduardo, Saad, Jose R, Enriz, Ricardo D, Rodriguez, Ana M, Jauregui, Esteban A, Guzman, Jorge, Maria, Alejandra O. M, Wendel, Graciela H
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Sprache:eng
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