Small Circular Oligodeoxynucleotides Achieved from Self-Assembling Entities

Small Circular Oligodeoxynucleotides Achieved from Self-Assembling Entities

Self‐recognition rather than complementarity defines the self‐assembly (a) of two cytosine‐rich oligodeoxynucleotides in the compact i‐motif shown (CC+ base pairs, dark circles). When the 5′‐terminal phosphate is activated, phosphodiester bonds form between the termini of the linear sequences, resu...

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Veröffentlicht in:Angewandte Chemie International Edition 2003-02, Vol.42 (7), p.797-799
Hauptverfasser: Liu, Dongsheng, Chen, Jian, Lee, Alex H. F., Chow, Larry M. C., Chan, Albert S. C., Li, Tianhu
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Cyclization
DNA structures
Nucleic Acid Conformation
Oligodeoxyribonucleotides - chemical synthesis
Oligodeoxyribonucleotides - chemistry
oligonucleotides
self-assembly
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Zusammenfassung:Self‐recognition rather than complementarity defines the self‐assembly (a) of two cytosine‐rich oligodeoxynucleotides in the compact i‐motif shown (CC+ base pairs, dark circles). When the 5′‐terminal phosphate is activated, phosphodiester bonds form between the termini of the linear sequences, resulting in two circular oligodeoxynucleotides (b), which disassociate on denaturation (c).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200390211