Intravenous Droperidol Causes a Reduction in the Bispectral Index in Propofol-Sedated Patients During Spinal Anesthesia
We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious gr...
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| Veröffentlicht in: | Anesthesia and analgesia 2003-03, Vol.96 (3), p.765-768 |
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| container_title | Anesthesia and analgesia |
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| creator | Nakayama, Masayasu Kanaya, Noriaki Ichinose, Hiromichi Yamamoto, Shuji Namiki, Akiyoshi |
| description | We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Another group of patients were sedated with a propofol infusion to maintain BIS at 60 ± 5 and were administered IV saline (placebo group;n = 20), droperidol 1 mg (dro-1 group;n = 20), or droperidol 2 mg (dro-2 group;n = 20) in a randomized order and in a double-blinded fashion. Although BIS remained the same in the conscious and placebo groups, it significantly decreased after administration of droperidol in the dro-1 and dro-2 groups. The decrease in BIS was significantly larger in the dro-2 group than in the dro-1 group. These results suggest that an antiemetic dose of droperidol enhances the hypnotic effect of propofol in a dose-dependent manner during spinal anesthesia. |
| doi_str_mv | 10.1213/01.ANE.0000048517.98692.53 |
| format | Article |
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Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Another group of patients were sedated with a propofol infusion to maintain BIS at 60 ± 5 and were administered IV saline (placebo group;n = 20), droperidol 1 mg (dro-1 group;n = 20), or droperidol 2 mg (dro-2 group;n = 20) in a randomized order and in a double-blinded fashion. Although BIS remained the same in the conscious and placebo groups, it significantly decreased after administration of droperidol in the dro-1 and dro-2 groups. The decrease in BIS was significantly larger in the dro-2 group than in the dro-1 group. These results suggest that an antiemetic dose of droperidol enhances the hypnotic effect of propofol in a dose-dependent manner during spinal anesthesia.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/01.ANE.0000048517.98692.53</identifier><identifier>PMID: 12598260</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Adult ; Anesthesia Recovery Period ; Anesthesia, Spinal ; Antipsychotic Agents - administration & dosage ; Antipsychotic Agents - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Conscious Sedation ; Double-Blind Method ; Droperidol - administration & dosage ; Droperidol - pharmacology ; Electroencephalography - drug effects ; Female ; Gynecologic Surgical Procedures ; Heart Rate - drug effects ; Humans ; Hypnotics and Sedatives ; Hypnotics. Sedatives ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Propofol ; Psychology. Psychoanalysis. 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Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Another group of patients were sedated with a propofol infusion to maintain BIS at 60 ± 5 and were administered IV saline (placebo group;n = 20), droperidol 1 mg (dro-1 group;n = 20), or droperidol 2 mg (dro-2 group;n = 20) in a randomized order and in a double-blinded fashion. Although BIS remained the same in the conscious and placebo groups, it significantly decreased after administration of droperidol in the dro-1 and dro-2 groups. The decrease in BIS was significantly larger in the dro-2 group than in the dro-1 group. These results suggest that an antiemetic dose of droperidol enhances the hypnotic effect of propofol in a dose-dependent manner during spinal anesthesia.</description><subject>Adult</subject><subject>Anesthesia Recovery Period</subject><subject>Anesthesia, Spinal</subject><subject>Antipsychotic Agents - administration & dosage</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Conscious Sedation</subject><subject>Double-Blind Method</subject><subject>Droperidol - administration & dosage</subject><subject>Droperidol - pharmacology</subject><subject>Electroencephalography - drug effects</subject><subject>Female</subject><subject>Gynecologic Surgical Procedures</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hypnotics and Sedatives</subject><subject>Hypnotics. Sedatives</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Propofol</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkV-P1CAUxYnRuOPqVzDERN9a-VMK-DaOq06y0Y2rz4SWWwdlaIXW0W8v40wyEEK4_M494YDQC0pqyih_TWi9_nRTk-NolKCy1qrVrBb8AVpRwdpKCq0eolW55xXTWl-hJzn_KEdKVPsYXVFWANaSFTps45zsb4jjkvG7NE6QvBsD3tglQ8YWfwG39LMfI_YRzzvAb32eoC-igLfRwZ9j_a4Ix2EM1T04O4PDd3b2EOfSckk-fsf3k49FsI6QS4_s7VP0aLAhw7Pzfo2-vb_5uvlY3X7-sN2sb6teECUqpTpBtGWMUNfQRvCOS0G7gSjSNaXWUtZRJYnTzA6NBtuBaByRVjpoWaf4NXp16jul8ddS3M3e5x5CsBHKk43khGlOSQHfnMA-jTknGMyU_N6mv4YSc4zdEGpK7OYSu_kfuxG8iJ-fXZZuD-4iPedcgJdnwObehiHZ2Pt84RohpeBt4ZoTdxjDDCn_DMsBktmBDfPuZC24rlj52DIJqcpigv8DkbubQQ</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Nakayama, Masayasu</creator><creator>Kanaya, Noriaki</creator><creator>Ichinose, Hiromichi</creator><creator>Yamamoto, Shuji</creator><creator>Namiki, Akiyoshi</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Intravenous Droperidol Causes a Reduction in the Bispectral Index in Propofol-Sedated Patients During Spinal Anesthesia</title><author>Nakayama, Masayasu ; Kanaya, Noriaki ; Ichinose, Hiromichi ; Yamamoto, Shuji ; Namiki, Akiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5085-88b509a2201d41453b3751bf080b401d612b1870d92af49eabe54d07a7de62b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Anesthesia Recovery Period</topic><topic>Anesthesia, Spinal</topic><topic>Antipsychotic Agents - administration & dosage</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Conscious Sedation</topic><topic>Double-Blind Method</topic><topic>Droperidol - administration & dosage</topic><topic>Droperidol - pharmacology</topic><topic>Electroencephalography - drug effects</topic><topic>Female</topic><topic>Gynecologic Surgical Procedures</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Hypnotics and Sedatives</topic><topic>Hypnotics. Sedatives</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Propofol</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakayama, Masayasu</creatorcontrib><creatorcontrib>Kanaya, Noriaki</creatorcontrib><creatorcontrib>Ichinose, Hiromichi</creatorcontrib><creatorcontrib>Yamamoto, Shuji</creatorcontrib><creatorcontrib>Namiki, Akiyoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakayama, Masayasu</au><au>Kanaya, Noriaki</au><au>Ichinose, Hiromichi</au><au>Yamamoto, Shuji</au><au>Namiki, Akiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous Droperidol Causes a Reduction in the Bispectral Index in Propofol-Sedated Patients During Spinal Anesthesia</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>96</volume><issue>3</issue><spage>765</spage><epage>768</epage><pages>765-768</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Another group of patients were sedated with a propofol infusion to maintain BIS at 60 ± 5 and were administered IV saline (placebo group;n = 20), droperidol 1 mg (dro-1 group;n = 20), or droperidol 2 mg (dro-2 group;n = 20) in a randomized order and in a double-blinded fashion. Although BIS remained the same in the conscious and placebo groups, it significantly decreased after administration of droperidol in the dro-1 and dro-2 groups. The decrease in BIS was significantly larger in the dro-2 group than in the dro-1 group. These results suggest that an antiemetic dose of droperidol enhances the hypnotic effect of propofol in a dose-dependent manner during spinal anesthesia.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>12598260</pmid><doi>10.1213/01.ANE.0000048517.98692.53</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anesthesia Recovery Period Anesthesia, Spinal Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacology Biological and medical sciences Blood Pressure - drug effects Conscious Sedation Double-Blind Method Droperidol - administration & dosage Droperidol - pharmacology Electroencephalography - drug effects Female Gynecologic Surgical Procedures Heart Rate - drug effects Humans Hypnotics and Sedatives Hypnotics. Sedatives Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Propofol Psychology. Psychoanalysis. Psychiatry Psychopharmacology |
| title | Intravenous Droperidol Causes a Reduction in the Bispectral Index in Propofol-Sedated Patients During Spinal Anesthesia |
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