Expression of active human blood clotting factor VIII in mammary gland of transgenic rabbits

Human clotting factor VIII is probably the largest protein to be expressed to date in the mammary gland of a transgenic animal, and it requires extensive posttranslational modification to achieve full biological activity. The mammary gland specific construct mWAP-hFVIII-MT-I was injected into the pr...

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Veröffentlicht in:	DNA and cell biology 2003-01, Vol.22 (1), p.41-45
Hauptverfasser:	Hiripi, L, Makovics, F, Halter, R, Baranyi, M, Paul, D, Carnwath, J W, Bösze, Zs, Niemann, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified - metabolism Blood Coagulation - physiology Factor VIII - genetics Factor VIII - metabolism Female Humans Lactation Mammary Glands, Animal - metabolism Milk - metabolism Rabbits
Online-Zugang:	Volltext
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