Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem‐cell transplantation

Objectives. Familial haemophagocytic lymphohistiocytosis (FHL) is a disorder characterized by deficient cytotoxic T‐cell function and activated macrophages, owing to a defect in the perforin gene and absent perforin expression. Because symptoms of patients with systemic juvenile idiopathic arthritis...

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Veröffentlicht in:	British journal of rheumatology 2003-02, Vol.42 (2), p.375-379
Hauptverfasser:	Wulffraat, N. M., Rijkers, G. T., Elst, E., Brooimans, R., Kuis, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arthritis, Juvenile - immunology Arthritis, Juvenile - therapy Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction CD8-Positive T-Lymphocytes - immunology Child Child, Preschool Diseases of the osteoarticular system Female Hematopoietic Stem Cell Transplantation Humans Inflammatory joint diseases Juvenile idiopathic arthritis Killer Cells, Natural - immunology Leukocyte Common Antigens - blood Male Medical sciences Membrane Glycoproteins - blood Membrane Glycoproteins - deficiency Perforin Perforin expression Pore Forming Cytotoxic Proteins Stem‐cell transplantation T-Lymphocyte Subsets - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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