Effects of chronic dietary choline on temporal discrimination of BN and WAG rats
Using rats of the inbred BN and WAG strain, we tested the hypothesis that chronic dietary choline supplementation would especially affect the timing behavior of BN rats because of their lower cholinergic activity and their poor performance in aversively motivated learning and memory tasks. An appare...
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| Veröffentlicht in: | Physiology & behavior 1992-05, Vol.51 (5), p.899-908 |
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| creator | van der Staay, F.Josef Raaijmakers, Wijnand G.M. Kerbusch, Sjeng |
| description | Using rats of the inbred BN and WAG strain, we tested the hypothesis that chronic dietary choline supplementation would especially affect the timing behavior of BN rats because of their lower cholinergic activity and their poor performance in aversively motivated learning and memory tasks. An apparent effect of chronic choline supplementation (2.5 mg choline chloride per ml water) on DRL-8″ responding was not confirmed in a second experiment when the choline concentration was doubled. WAG rats treated chronically with choline showed a poorer temporal discrimination performance on a DRL-16″ schedule than untreated WAG rats. In contrast, choline supplementation never had an effect on the performance of BN rats. The results of the DRL-16″ experiment provide partial support for a hypothesis proposed by Church and Meck that the remembered time of reinforcement is inversely related to the functional activity of brain cholinergic activity: acetylcholine precursor treatment increases memory storage speed, which results in an overestimation of the time elapsed. An alternative explanation, which takes into account the aberrant EEG activities of WAG rats, is also discussed. |
| doi_str_mv | 10.1016/0031-9384(92)90068-D |
| format | Article |
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An apparent effect of chronic choline supplementation (2.5 mg choline chloride per ml water) on DRL-8″ responding was not confirmed in a second experiment when the choline concentration was doubled. WAG rats treated chronically with choline showed a poorer temporal discrimination performance on a DRL-16″ schedule than untreated WAG rats. In contrast, choline supplementation never had an effect on the performance of BN rats. The results of the DRL-16″ experiment provide partial support for a hypothesis proposed by Church and Meck that the remembered time of reinforcement is inversely related to the functional activity of brain cholinergic activity: acetylcholine precursor treatment increases memory storage speed, which results in an overestimation of the time elapsed. An alternative explanation, which takes into account the aberrant EEG activities of WAG rats, is also discussed.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(92)90068-D</identifier><identifier>PMID: 1615050</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Acetylcholine ; Acetylcholine - physiology ; Albino Wistar rats ; Animals ; Arousal - drug effects ; Arousal - physiology ; Avoidance Learning - drug effects ; Avoidance Learning - physiology ; Biological and medical sciences ; Brown Norway rats ; Choline - pharmacology ; Chronic dietary choline ; Cognition. Intelligence ; Discrimination Learning - drug effects ; Discrimination Learning - physiology ; DRL ; Extinction, Psychological - drug effects ; Extinction, Psychological - physiology ; Fundamental and applied biological sciences. Psychology ; Male ; Mental Recall - drug effects ; Mental Recall - physiology ; Orientation - drug effects ; Orientation - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Inbred BN ; Rats, Inbred Strains ; Reaction Time - drug effects ; Reaction Time - physiology ; Reinforcement Schedule ; Retention (Psychology) - drug effects ; Retention (Psychology) - physiology ; Spatial perception. 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An apparent effect of chronic choline supplementation (2.5 mg choline chloride per ml water) on DRL-8″ responding was not confirmed in a second experiment when the choline concentration was doubled. WAG rats treated chronically with choline showed a poorer temporal discrimination performance on a DRL-16″ schedule than untreated WAG rats. In contrast, choline supplementation never had an effect on the performance of BN rats. The results of the DRL-16″ experiment provide partial support for a hypothesis proposed by Church and Meck that the remembered time of reinforcement is inversely related to the functional activity of brain cholinergic activity: acetylcholine precursor treatment increases memory storage speed, which results in an overestimation of the time elapsed. An alternative explanation, which takes into account the aberrant EEG activities of WAG rats, is also discussed.</description><subject>Acetylcholine</subject><subject>Acetylcholine - physiology</subject><subject>Albino Wistar rats</subject><subject>Animals</subject><subject>Arousal - drug effects</subject><subject>Arousal - physiology</subject><subject>Avoidance Learning - drug effects</subject><subject>Avoidance Learning - physiology</subject><subject>Biological and medical sciences</subject><subject>Brown Norway rats</subject><subject>Choline - pharmacology</subject><subject>Chronic dietary choline</subject><subject>Cognition. Intelligence</subject><subject>Discrimination Learning - drug effects</subject><subject>Discrimination Learning - physiology</subject><subject>DRL</subject><subject>Extinction, Psychological - drug effects</subject><subject>Extinction, Psychological - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Mental Recall - drug effects</subject><subject>Mental Recall - physiology</subject><subject>Orientation - drug effects</subject><subject>Orientation - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>Rats, Inbred Strains</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Reinforcement Schedule</subject><subject>Retention (Psychology) - drug effects</subject><subject>Retention (Psychology) - physiology</subject><subject>Spatial perception. Time perception</subject><subject>Species Specificity</subject><subject>Strain differences</subject><subject>Temporal discrimination learning</subject><subject>Time Perception - drug effects</subject><subject>Time Perception - physiology</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OAyEURonRaK2-gSazMEYXo_wMMGxMaq3VxKgLje4IMBAx06HC1MS3l9pGd7Ih8J17c-8B4ADBMwQRO4eQoFKQujoR-FRAyOryagMMUM1JSSF_3QSDX2QH7Kb0DvMhFdkG24ghCikcgMeJc9b0qQiuMG8xdN4Ujbe9il_5HVrf2SJ0RW9n8xBVm7Nkop_5TvU-_-eqy_tCdU3xMpoWUfVpD2w51Sa7v76H4Pl68jS-Ke8eprfj0V1pSM36ktREa9ZwQ3HFkVZGQ6MRdxVtMHJaY4oEdoIyZynCQiuGeaMwF5xgaokiQ3C86juP4WNhUy9neTTbtqqzYZEkJxDXnKEMVivQxJBStE7O8wJ5P4mgXIqUS0tyaUkKLH9Eyqtcdrjuv9Az2_wVrczl_Gidq2RU66LqjE-_GK0oFGyJXawwm118ehtlMt52xjY-Zu-yCf7_Ob4BLcyN5Q</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>van der Staay, F.Josef</creator><creator>Raaijmakers, Wijnand G.M.</creator><creator>Kerbusch, Sjeng</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>Effects of chronic dietary choline on temporal discrimination of BN and WAG rats</title><author>van der Staay, F.Josef ; Raaijmakers, Wijnand G.M. ; Kerbusch, Sjeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-383bb6d7c52471bacb0cb17f45d21fbb25192f956fe5129ba627da2797325e3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acetylcholine</topic><topic>Acetylcholine - physiology</topic><topic>Albino Wistar rats</topic><topic>Animals</topic><topic>Arousal - drug effects</topic><topic>Arousal - physiology</topic><topic>Avoidance Learning - drug effects</topic><topic>Avoidance Learning - physiology</topic><topic>Biological and medical sciences</topic><topic>Brown Norway rats</topic><topic>Choline - pharmacology</topic><topic>Chronic dietary choline</topic><topic>Cognition. Intelligence</topic><topic>Discrimination Learning - drug effects</topic><topic>Discrimination Learning - physiology</topic><topic>DRL</topic><topic>Extinction, Psychological - drug effects</topic><topic>Extinction, Psychological - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Mental Recall - drug effects</topic><topic>Mental Recall - physiology</topic><topic>Orientation - drug effects</topic><topic>Orientation - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>Rats, Inbred Strains</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Reinforcement Schedule</topic><topic>Retention (Psychology) - drug effects</topic><topic>Retention (Psychology) - physiology</topic><topic>Spatial perception. Time perception</topic><topic>Species Specificity</topic><topic>Strain differences</topic><topic>Temporal discrimination learning</topic><topic>Time Perception - drug effects</topic><topic>Time Perception - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Staay, F.Josef</creatorcontrib><creatorcontrib>Raaijmakers, Wijnand G.M.</creatorcontrib><creatorcontrib>Kerbusch, Sjeng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Staay, F.Josef</au><au>Raaijmakers, Wijnand G.M.</au><au>Kerbusch, Sjeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of chronic dietary choline on temporal discrimination of BN and WAG rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>51</volume><issue>5</issue><spage>899</spage><epage>908</epage><pages>899-908</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Using rats of the inbred BN and WAG strain, we tested the hypothesis that chronic dietary choline supplementation would especially affect the timing behavior of BN rats because of their lower cholinergic activity and their poor performance in aversively motivated learning and memory tasks. An apparent effect of chronic choline supplementation (2.5 mg choline chloride per ml water) on DRL-8″ responding was not confirmed in a second experiment when the choline concentration was doubled. WAG rats treated chronically with choline showed a poorer temporal discrimination performance on a DRL-16″ schedule than untreated WAG rats. In contrast, choline supplementation never had an effect on the performance of BN rats. The results of the DRL-16″ experiment provide partial support for a hypothesis proposed by Church and Meck that the remembered time of reinforcement is inversely related to the functional activity of brain cholinergic activity: acetylcholine precursor treatment increases memory storage speed, which results in an overestimation of the time elapsed. An alternative explanation, which takes into account the aberrant EEG activities of WAG rats, is also discussed.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1615050</pmid><doi>10.1016/0031-9384(92)90068-D</doi><tpages>10</tpages></addata></record> |
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| subjects | Acetylcholine Acetylcholine - physiology Albino Wistar rats Animals Arousal - drug effects Arousal - physiology Avoidance Learning - drug effects Avoidance Learning - physiology Biological and medical sciences Brown Norway rats Choline - pharmacology Chronic dietary choline Cognition. Intelligence Discrimination Learning - drug effects Discrimination Learning - physiology DRL Extinction, Psychological - drug effects Extinction, Psychological - physiology Fundamental and applied biological sciences. Psychology Male Mental Recall - drug effects Mental Recall - physiology Orientation - drug effects Orientation - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred BN Rats, Inbred Strains Reaction Time - drug effects Reaction Time - physiology Reinforcement Schedule Retention (Psychology) - drug effects Retention (Psychology) - physiology Spatial perception. Time perception Species Specificity Strain differences Temporal discrimination learning Time Perception - drug effects Time Perception - physiology |
| title | Effects of chronic dietary choline on temporal discrimination of BN and WAG rats |
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