Androgen Regulation of Parathyroid Hormone-Related Peptide Production in Human Prostate Cancer Cells

PTHrP is the major pathogenetic factor for hypercalcemia in several malignancies including prostate cancer. In the current study, we have assessed the ability of androgens to regulate PTHrP production in androgen-insensitive human prostate cancer cells PC-3 and cells transfected with androgen recept...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2003-03, Vol.144 (3), p.858-867
Hauptverfasser:	Pizzi, Helena, Gladu, Julienne, Carpio, Luisa, Miao, Dengshun, Goltzman, David, Rabbani, Shafaat A
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Androgens Androgens - physiology Animals Biological and medical sciences Cell Division - drug effects Cell growth Dihydrotestosterone Dihydrotestosterone - pharmacology Flutamide Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression Regulation - drug effects Gene regulation Human parathyroid hormone Human performance Humans Hypercalcemia Immunohistochemistry In vivo methods and tests Inoculation Male Malignancy Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Orchiectomy Parathyroid hormone Parathyroid Hormone-Related Protein Peptide Hormones - analysis Peptide Hormones - biosynthesis Peptide Hormones - genetics Promoter Regions, Genetic Prostate cancer Prostatic Neoplasms - chemistry Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Rats Receptors Receptors, Androgen - genetics Receptors, Androgen - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Transfection Tumor Cells, Cultured Tumors
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