Defensive burying following injections of cholecystokinin, bombesin, and LiCl in rats
Past research indicates that feeding is reduced for animals injected with cholecystokinin and bombesin. One explanation for this effect suggests that these peptides act as natural satiety signals; an opposing view asserts that bombesin and cholecystokinin reduce feeding through malaise. The present...
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| Veröffentlicht in: | Physiology & behavior 1992-05, Vol.51 (5), p.969-972 |
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| container_title | Physiology & behavior |
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| creator | Bowers, Robin L. Herzog, Christopher D. Stone, Eric H. Dionne, Thomas J. |
| description | Past research indicates that feeding is reduced for animals injected with cholecystokinin and bombesin. One explanation for this effect suggests that these peptides act as natural satiety signals; an opposing view asserts that bombesin and cholecystokinin reduce feeding through malaise. The present experiment tested the basic assumptions associated with these positions using the defensive burying procedure. Groups of rats were given sweetened condensed milk followed by IP injections of bombesin (6,16, and 32 μg/kg), cholecystokinin (0.7, 1.4, and 2.9 μg/kg), LiCl (6.4 mg/ml), or saline. The results showed that animals injected with cholecystokinin, bombesin, and LiCl developed learned aversions to the milk and actively buried the milk spout with their bedding. The findings provide further support for the view that bombesin and cholecystokinin induce malaise rather than satiety. |
| doi_str_mv | 10.1016/0031-9384(92)90079-H |
| format | Article |
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One explanation for this effect suggests that these peptides act as natural satiety signals; an opposing view asserts that bombesin and cholecystokinin reduce feeding through malaise. The present experiment tested the basic assumptions associated with these positions using the defensive burying procedure. Groups of rats were given sweetened condensed milk followed by IP injections of bombesin (6,16, and 32 μg/kg), cholecystokinin (0.7, 1.4, and 2.9 μg/kg), LiCl (6.4 mg/ml), or saline. The results showed that animals injected with cholecystokinin, bombesin, and LiCl developed learned aversions to the milk and actively buried the milk spout with their bedding. The findings provide further support for the view that bombesin and cholecystokinin induce malaise rather than satiety.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(92)90079-H</identifier><identifier>PMID: 1319591</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Animals ; Appetitive Behavior - drug effects ; Arousal - drug effects ; Association Learning - drug effects ; Avoidance Learning - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Bombesin ; Bombesin - pharmacology ; Chlorides - pharmacology ; Cholecystokinin ; Conditioning, Classical - drug effects ; Defensive burying ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Hormones and behavior ; Learned aversion ; Lithium - pharmacology ; Lithium Chloride ; Malaise ; Male ; Motivation ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Inbred Strains ; Satiety ; Satiety Response - drug effects ; Sincalide - pharmacology ; Species-specific defense reactions ; Unconditioned stimuli</subject><ispartof>Physiology & behavior, 1992-05, Vol.51 (5), p.969-972</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-e09335d0831d54d29a583f0d0d49cbb374ac5c7231a1fc73364e32c9b01c9f203</citedby><cites>FETCH-LOGICAL-c386t-e09335d0831d54d29a583f0d0d49cbb374ac5c7231a1fc73364e32c9b01c9f203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0031-9384(92)90079-H$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5450968$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1319591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bowers, Robin L.</creatorcontrib><creatorcontrib>Herzog, Christopher D.</creatorcontrib><creatorcontrib>Stone, Eric H.</creatorcontrib><creatorcontrib>Dionne, Thomas J.</creatorcontrib><title>Defensive burying following injections of cholecystokinin, bombesin, and LiCl in rats</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Past research indicates that feeding is reduced for animals injected with cholecystokinin and bombesin. One explanation for this effect suggests that these peptides act as natural satiety signals; an opposing view asserts that bombesin and cholecystokinin reduce feeding through malaise. The present experiment tested the basic assumptions associated with these positions using the defensive burying procedure. Groups of rats were given sweetened condensed milk followed by IP injections of bombesin (6,16, and 32 μg/kg), cholecystokinin (0.7, 1.4, and 2.9 μg/kg), LiCl (6.4 mg/ml), or saline. The results showed that animals injected with cholecystokinin, bombesin, and LiCl developed learned aversions to the milk and actively buried the milk spout with their bedding. The findings provide further support for the view that bombesin and cholecystokinin induce malaise rather than satiety.</description><subject>Animals</subject><subject>Appetitive Behavior - drug effects</subject><subject>Arousal - drug effects</subject><subject>Association Learning - drug effects</subject><subject>Avoidance Learning - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Bombesin</subject><subject>Bombesin - pharmacology</subject><subject>Chlorides - pharmacology</subject><subject>Cholecystokinin</subject><subject>Conditioning, Classical - drug effects</subject><subject>Defensive burying</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and behavior</subject><subject>Learned aversion</subject><subject>Lithium - pharmacology</subject><subject>Lithium Chloride</subject><subject>Malaise</subject><subject>Male</subject><subject>Motivation</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Satiety</subject><subject>Satiety Response - drug effects</subject><subject>Sincalide - pharmacology</subject><subject>Species-specific defense reactions</subject><subject>Unconditioned stimuli</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVoSLfbvEELPpTQQtyOPPbKugTCJs0WFnppoDchS6NWqVdKJG_Cvn3t7pLcOpcZmO8fho-xdxw-c-CLLwDIS4lt_VFWnySAkOXqiM14K7BsQPx8xWbPyGv2Juc7GAtrPGEnHLlsJJ-x2ytyFLJ_pKLbpp0PvwoX-z4-TZMPd2QGH0MuoivM79iT2eUh_vHBh_Oii5uO8jTpYIu1X_Zjokh6yG_ZsdN9ptNDn7Pbr9c_lqty_f3m2_JyXRpsF0NJIBEbCy1y29S2krpp0YEFW0vTdShqbRojKuSaOyMQFzVhZWQH3EhXAc7Z2f7ufYoPW8qD2vhsqO91oLjNSiBUQozBOav3oEkx50RO3Se_0WmnOKjJpppUqUmVkpX6Z1Otxtj7w_1ttyH7EtrrG_cfDnudje5d0sH4_Iw1dQNy0Y7YxR6j0cWjp6Sy8RQMWZ9GwcpG__8__gKHa5Bs</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Bowers, Robin L.</creator><creator>Herzog, Christopher D.</creator><creator>Stone, Eric H.</creator><creator>Dionne, Thomas J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>Defensive burying following injections of cholecystokinin, bombesin, and LiCl in rats</title><author>Bowers, Robin L. ; Herzog, Christopher D. ; Stone, Eric H. ; Dionne, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-e09335d0831d54d29a583f0d0d49cbb374ac5c7231a1fc73364e32c9b01c9f203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Appetitive Behavior - drug effects</topic><topic>Arousal - drug effects</topic><topic>Association Learning - drug effects</topic><topic>Avoidance Learning - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Bombesin</topic><topic>Bombesin - pharmacology</topic><topic>Chlorides - pharmacology</topic><topic>Cholecystokinin</topic><topic>Conditioning, Classical - drug effects</topic><topic>Defensive burying</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and behavior</topic><topic>Learned aversion</topic><topic>Lithium - pharmacology</topic><topic>Lithium Chloride</topic><topic>Malaise</topic><topic>Male</topic><topic>Motivation</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Satiety</topic><topic>Satiety Response - drug effects</topic><topic>Sincalide - pharmacology</topic><topic>Species-specific defense reactions</topic><topic>Unconditioned stimuli</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowers, Robin L.</creatorcontrib><creatorcontrib>Herzog, Christopher D.</creatorcontrib><creatorcontrib>Stone, Eric H.</creatorcontrib><creatorcontrib>Dionne, Thomas J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowers, Robin L.</au><au>Herzog, Christopher D.</au><au>Stone, Eric H.</au><au>Dionne, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Defensive burying following injections of cholecystokinin, bombesin, and LiCl in rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>51</volume><issue>5</issue><spage>969</spage><epage>972</epage><pages>969-972</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Past research indicates that feeding is reduced for animals injected with cholecystokinin and bombesin. One explanation for this effect suggests that these peptides act as natural satiety signals; an opposing view asserts that bombesin and cholecystokinin reduce feeding through malaise. The present experiment tested the basic assumptions associated with these positions using the defensive burying procedure. Groups of rats were given sweetened condensed milk followed by IP injections of bombesin (6,16, and 32 μg/kg), cholecystokinin (0.7, 1.4, and 2.9 μg/kg), LiCl (6.4 mg/ml), or saline. The results showed that animals injected with cholecystokinin, bombesin, and LiCl developed learned aversions to the milk and actively buried the milk spout with their bedding. The findings provide further support for the view that bombesin and cholecystokinin induce malaise rather than satiety.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1319591</pmid><doi>10.1016/0031-9384(92)90079-H</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Appetitive Behavior - drug effects Arousal - drug effects Association Learning - drug effects Avoidance Learning - drug effects Behavioral psychophysiology Biological and medical sciences Bombesin Bombesin - pharmacology Chlorides - pharmacology Cholecystokinin Conditioning, Classical - drug effects Defensive burying Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Hormones and behavior Learned aversion Lithium - pharmacology Lithium Chloride Malaise Male Motivation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Strains Satiety Satiety Response - drug effects Sincalide - pharmacology Species-specific defense reactions Unconditioned stimuli |
| title | Defensive burying following injections of cholecystokinin, bombesin, and LiCl in rats |
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