In vitro penetration of des-tyrosine1-D-phenylalanine3-β-casomorphin across the blood-brain barrier

The blood-brain barrier transport and metabolism of the synthetic beta-casomorphin (beta CM) derivative des-tyrosine1-D-phenylalanine3-beta-casomorphin (DT-D-Phe3-beta CM) were investigated using an in vitro model consisting of primary cultures of bovine cerebrovascular endothelial cells. DT-D-Phe3-...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1992, Vol.13 (1), p.47-51
Hauptverfasser:	STARK, H, VAN BREE, J. B. M. M, DE BOER, A. G, JAEHDE, U, BREIMER, D. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport - drug effects Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Brain - physiology Cattle Cells, Cultured Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Deoxyglucose - pharmacology Endorphins - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Metabolic Clearance Rate Peptide Fragments - metabolism Permeability - drug effects Vertebrates: nervous system and sense organs
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