Stem and progenitor cells: the premature desertion of rigorous definitions
A current disturbing trend in stem cell biology is the abandonment of rigorous definitions of stem and progenitor cells in favor of more ambiguous, all-encompassing concepts. However, recent studies suggest that there are consistent, functional differences in the biology of these two cell types. Adm...
Gespeichert in:
| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2003-03, Vol.26 (3), p.125-131 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 131 |
|---|---|
| container_issue | 3 |
| container_start_page | 125 |
| container_title | Trends in neurosciences (Regular ed.) |
| container_volume | 26 |
| creator | Seaberg, Raewyn M van der Kooy, Derek |
| description | A current disturbing trend in stem cell biology is the abandonment of rigorous definitions of stem and progenitor cells in favor of more ambiguous, all-encompassing concepts. However, recent studies suggest that there are consistent, functional differences in the biology of these two cell types. Admittedly, it can be difficult to harmonize the
in vivo and
in vitro functional differences between stem and progenitor cells. Nonetheless, these distinctions between cell types should be emphasized rather than ignored, as they can be used to test specific hypotheses in neural stem cell biology. |
| doi_str_mv | 10.1016/S0166-2236(03)00031-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73025434</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166223603000316</els_id><sourcerecordid>73025434</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-192a41bb19b160632aff0326ad10dad7a5e81dcc08edc543e778316f8b133e923</originalsourceid><addsrcrecordid>eNqFkV9rFDEUxYNY3HX1IyiDYLEPo_cmM5mML1IW7R8WfKiCbyGT3KkpO5OazBT67c12Fwu-9CWBy-9czj2HsTcIHxFQfrrKjyw5F_IDiBMAEFjKZ2yJqlElgvr1nC3_IQv2MqUbAKwUVi_YAnndIsdqyS6vJhoKM7riNoZrGv0UYmFpu02fi-k35SkNZpojFY4SxcmHsQh9Ef11iGFOedr7LMrj9Iod9Wab6PXhX7Gf377-WJ-Xm-9nF-vTTWlrrKcSW24q7DpsO5QgBTd9D4JL4xCccY2pSaGzFhQ5W1eCmkYJlL3qUAhquVix4_3e7PjPTGnSg087y2akbEk3AnjWVU-CqGQrpFQZfPcfeBPmOOYjNM95YgNNnaF6D9kYUorU69voBxPvNYLeVaIfKtG7vDUI_VCJlln39rB87gZyj6pDBxl4fwBMsmbbRzNanx65mitsm92iL3uOcrh3nqJO1tNoyflIdtIu-Ces_AUkWacA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218717075</pqid></control><display><type>article</type><title>Stem and progenitor cells: the premature desertion of rigorous definitions</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Seaberg, Raewyn M ; van der Kooy, Derek</creator><creatorcontrib>Seaberg, Raewyn M ; van der Kooy, Derek</creatorcontrib><description>A current disturbing trend in stem cell biology is the abandonment of rigorous definitions of stem and progenitor cells in favor of more ambiguous, all-encompassing concepts. However, recent studies suggest that there are consistent, functional differences in the biology of these two cell types. Admittedly, it can be difficult to harmonize the
in vivo and
in vitro functional differences between stem and progenitor cells. Nonetheless, these distinctions between cell types should be emphasized rather than ignored, as they can be used to test specific hypotheses in neural stem cell biology.</description><identifier>ISSN: 0166-2236</identifier><identifier>EISSN: 1878-108X</identifier><identifier>DOI: 10.1016/S0166-2236(03)00031-6</identifier><identifier>PMID: 12591214</identifier><identifier>CODEN: TNSCDR</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cellular biology ; Fundamental and applied biological sciences. Psychology ; General aspects. Models. Methods ; Neurobiology - trends ; Neurology ; Neurons - metabolism ; Stem cells ; Stem Cells - metabolism ; Terminology as Topic ; Vertebrates: nervous system and sense organs</subject><ispartof>Trends in neurosciences (Regular ed.), 2003-03, Vol.26 (3), p.125-131</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Mar 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-192a41bb19b160632aff0326ad10dad7a5e81dcc08edc543e778316f8b133e923</citedby><cites>FETCH-LOGICAL-c515t-192a41bb19b160632aff0326ad10dad7a5e81dcc08edc543e778316f8b133e923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166223603000316$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15281976$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12591214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seaberg, Raewyn M</creatorcontrib><creatorcontrib>van der Kooy, Derek</creatorcontrib><title>Stem and progenitor cells: the premature desertion of rigorous definitions</title><title>Trends in neurosciences (Regular ed.)</title><addtitle>Trends Neurosci</addtitle><description>A current disturbing trend in stem cell biology is the abandonment of rigorous definitions of stem and progenitor cells in favor of more ambiguous, all-encompassing concepts. However, recent studies suggest that there are consistent, functional differences in the biology of these two cell types. Admittedly, it can be difficult to harmonize the
in vivo and
in vitro functional differences between stem and progenitor cells. Nonetheless, these distinctions between cell types should be emphasized rather than ignored, as they can be used to test specific hypotheses in neural stem cell biology.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cellular biology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Models. Methods</subject><subject>Neurobiology - trends</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Stem cells</subject><subject>Stem Cells - metabolism</subject><subject>Terminology as Topic</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0166-2236</issn><issn>1878-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYNY3HX1IyiDYLEPo_cmM5mML1IW7R8WfKiCbyGT3KkpO5OazBT67c12Fwu-9CWBy-9czj2HsTcIHxFQfrrKjyw5F_IDiBMAEFjKZ2yJqlElgvr1nC3_IQv2MqUbAKwUVi_YAnndIsdqyS6vJhoKM7riNoZrGv0UYmFpu02fi-k35SkNZpojFY4SxcmHsQh9Ef11iGFOedr7LMrj9Iod9Wab6PXhX7Gf377-WJ-Xm-9nF-vTTWlrrKcSW24q7DpsO5QgBTd9D4JL4xCccY2pSaGzFhQ5W1eCmkYJlL3qUAhquVix4_3e7PjPTGnSg087y2akbEk3AnjWVU-CqGQrpFQZfPcfeBPmOOYjNM95YgNNnaF6D9kYUorU69voBxPvNYLeVaIfKtG7vDUI_VCJlln39rB87gZyj6pDBxl4fwBMsmbbRzNanx65mitsm92iL3uOcrh3nqJO1tNoyflIdtIu-Ces_AUkWacA</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Seaberg, Raewyn M</creator><creator>van der Kooy, Derek</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><general>Elsevier Sequoia S.A</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Stem and progenitor cells: the premature desertion of rigorous definitions</title><author>Seaberg, Raewyn M ; van der Kooy, Derek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-192a41bb19b160632aff0326ad10dad7a5e81dcc08edc543e778316f8b133e923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cellular biology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Models. Methods</topic><topic>Neurobiology - trends</topic><topic>Neurology</topic><topic>Neurons - metabolism</topic><topic>Stem cells</topic><topic>Stem Cells - metabolism</topic><topic>Terminology as Topic</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seaberg, Raewyn M</creatorcontrib><creatorcontrib>van der Kooy, Derek</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in neurosciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seaberg, Raewyn M</au><au>van der Kooy, Derek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stem and progenitor cells: the premature desertion of rigorous definitions</atitle><jtitle>Trends in neurosciences (Regular ed.)</jtitle><addtitle>Trends Neurosci</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>26</volume><issue>3</issue><spage>125</spage><epage>131</epage><pages>125-131</pages><issn>0166-2236</issn><eissn>1878-108X</eissn><coden>TNSCDR</coden><abstract>A current disturbing trend in stem cell biology is the abandonment of rigorous definitions of stem and progenitor cells in favor of more ambiguous, all-encompassing concepts. However, recent studies suggest that there are consistent, functional differences in the biology of these two cell types. Admittedly, it can be difficult to harmonize the
in vivo and
in vitro functional differences between stem and progenitor cells. Nonetheless, these distinctions between cell types should be emphasized rather than ignored, as they can be used to test specific hypotheses in neural stem cell biology.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12591214</pmid><doi>10.1016/S0166-2236(03)00031-6</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-2236 |
| ispartof | Trends in neurosciences (Regular ed.), 2003-03, Vol.26 (3), p.125-131 |
| issn | 0166-2236 1878-108X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73025434 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cellular biology Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Neurobiology - trends Neurology Neurons - metabolism Stem cells Stem Cells - metabolism Terminology as Topic Vertebrates: nervous system and sense organs |
| title | Stem and progenitor cells: the premature desertion of rigorous definitions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T17%3A35%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stem%20and%20progenitor%20cells:%20the%20premature%20desertion%20of%20rigorous%20definitions&rft.jtitle=Trends%20in%20neurosciences%20(Regular%20ed.)&rft.au=Seaberg,%20Raewyn%20M&rft.date=2003-03-01&rft.volume=26&rft.issue=3&rft.spage=125&rft.epage=131&rft.pages=125-131&rft.issn=0166-2236&rft.eissn=1878-108X&rft.coden=TNSCDR&rft_id=info:doi/10.1016/S0166-2236(03)00031-6&rft_dat=%3Cproquest_cross%3E73025434%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218717075&rft_id=info:pmid/12591214&rft_els_id=S0166223603000316&rfr_iscdi=true |