Constrained Intracellular Survival of Mycobacterium tuberculosis in Human Dendritic Cells

Dendritic cells (DCs) are likely to play a key role in immunity against Mycobacterium tuberculosis, but the fate of the bacterium in these cells is still unknown. Here we report that, unlike macrophages (Mphis), human monocyte-derived DCs are not permissive for the growth of virulent M. tuberculosis...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-02, Vol.170 (4), p.1939-1948
Hauptverfasser:	Tailleux, Ludovic, Neyrolles, Olivier, Honore-Bouakline, Stephanie, Perret, Emmanuelle, Sanchez, Francoise, Abastado, Jean-Pierre, Lagrange, Philippe Henri, Gluckman, Jean Claude, Rosenzwajg, Michelle, Herrmann, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation Cell Differentiation - immunology Cell Division - immunology Cells, Cultured Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - microbiology Humans Immunity, Innate Intracellular Fluid - immunology Intracellular Fluid - metabolism Intracellular Fluid - microbiology Macrophages - immunology Macrophages - microbiology Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Phagosomes - immunology Phagosomes - microbiology Protein Biosynthesis Species Specificity Tuberculin - immunology Tuberculin - metabolism Vacuoles - immunology Vacuoles - microbiology
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