Inhibition of N8-acetylspermidine deacetylase by active-site-directed metal coordinating inhibitors

A number of substrate analogues of N8-acetylspermidine (N8-AcSpd) (16) and chemical modifying agents containing metal coordinating ligands were assayed as inhibitors of the cytoplasmic enzyme N8-AcSpd deacetylase from rat liver. The enzyme is inhibited by metal chelators, several omega-amino-substit...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-06, Vol.35 (13), p.2414-2418
Hauptverfasser:	Huang, Tien L, Dredar, Sasi A, Manneh, Victor A, Blankenship, James W, Fries, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Amidohydrolases - antagonists & inhibitors Animals Binding Sites Chemistry Enzyme Inhibitors - pharmacology Exact sciences and technology Liver - enzymology Metals - metabolism Organic chemistry Preparations and properties Rats
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