Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy
Purpose: To assess the spatial variability of a bladder tumor relative to the planning target volume boundaries during radical radiotherapy, and furthermore to develop strategies to reduce spatial variability. Methods and Materials: Seventeen patients with solitary T2–T4N0M0 bladder cancer were trea...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2003-03, Vol.55 (3), p.835-841 |
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| creator | Pos, Floris J Koedooder, Kees Hulshof, Maarten C.C.M van Tienhoven, Geertjan González González, Dionisio |
| description | Purpose: To assess the spatial variability of a bladder tumor relative to the planning target volume boundaries during radical radiotherapy, and furthermore to develop strategies to reduce spatial variability.
Methods and Materials: Seventeen patients with solitary T2–T4N0M0 bladder cancer were treated with a technique delivering 40 Gy/2 Gy in 20 fractions to the whole bladder with a concomitant boost to the bladder tumor of 20 Gy in 1 Gy fractions in an overall time of 4 weeks. CT scans were made weekly, immediately after treatment, and matched with the planning CT scan. Spatial variability of the tumor, as well as bladder volume and rectal diameter, were scored for each patient each week.
Results: In 65% of patients, a part of the tumor appeared outside the planning target volume boundaries at least one time during the course of radiotherapy. No consistent relation of this variability with time was found. Bladder volumes and rectal diameters showed marked variability during the course of treatment. A large initial bladder volume and rectal diameter predicted a large volume variation and a large tumor spatial variability.
Conclusion: In this study, a margin of 1.5 to 2 cm seemed to be inadequate in 65% of the patients with respect to spatial variability. Bladder volume and rectal diameter were found to be predictive for spatial variability of a bladder tumor during concomitant boost radiotherapy. |
| doi_str_mv | 10.1016/S0360-3016(02)04158-5 |
| format | Article |
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Methods and Materials: Seventeen patients with solitary T2–T4N0M0 bladder cancer were treated with a technique delivering 40 Gy/2 Gy in 20 fractions to the whole bladder with a concomitant boost to the bladder tumor of 20 Gy in 1 Gy fractions in an overall time of 4 weeks. CT scans were made weekly, immediately after treatment, and matched with the planning CT scan. Spatial variability of the tumor, as well as bladder volume and rectal diameter, were scored for each patient each week.
Results: In 65% of patients, a part of the tumor appeared outside the planning target volume boundaries at least one time during the course of radiotherapy. No consistent relation of this variability with time was found. Bladder volumes and rectal diameters showed marked variability during the course of treatment. A large initial bladder volume and rectal diameter predicted a large volume variation and a large tumor spatial variability.
Conclusion: In this study, a margin of 1.5 to 2 cm seemed to be inadequate in 65% of the patients with respect to spatial variability. Bladder volume and rectal diameter were found to be predictive for spatial variability of a bladder tumor during concomitant boost radiotherapy.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/S0360-3016(02)04158-5</identifier><identifier>PMID: 12573771</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Bladder cancer ; Conformal radiotherapy ; Humans ; Medical sciences ; Movement ; Organ motion ; Quality assurance ; Radiotherapy Dosage ; Radiotherapy, Conformal - methods ; Rectum - anatomy & histology ; Rectum - diagnostic imaging ; Time Factors ; Tomography, X-Ray Computed ; Urinary Bladder - anatomy & histology ; Urinary Bladder - diagnostic imaging ; Urinary Bladder Neoplasms - diagnostic imaging ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - radiotherapy</subject><ispartof>International journal of radiation oncology, biology, physics, 2003-03, Vol.55 (3), p.835-841</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-d39c5eab535e4bc86a40a378a12c2c4ea0090911a64bc074565e35e7f3a101b13</citedby><cites>FETCH-LOGICAL-c391t-d39c5eab535e4bc86a40a378a12c2c4ea0090911a64bc074565e35e7f3a101b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301602041585$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14564689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12573771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pos, Floris J</creatorcontrib><creatorcontrib>Koedooder, Kees</creatorcontrib><creatorcontrib>Hulshof, Maarten C.C.M</creatorcontrib><creatorcontrib>van Tienhoven, Geertjan</creatorcontrib><creatorcontrib>González González, Dionisio</creatorcontrib><title>Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose: To assess the spatial variability of a bladder tumor relative to the planning target volume boundaries during radical radiotherapy, and furthermore to develop strategies to reduce spatial variability.
Methods and Materials: Seventeen patients with solitary T2–T4N0M0 bladder cancer were treated with a technique delivering 40 Gy/2 Gy in 20 fractions to the whole bladder with a concomitant boost to the bladder tumor of 20 Gy in 1 Gy fractions in an overall time of 4 weeks. CT scans were made weekly, immediately after treatment, and matched with the planning CT scan. Spatial variability of the tumor, as well as bladder volume and rectal diameter, were scored for each patient each week.
Results: In 65% of patients, a part of the tumor appeared outside the planning target volume boundaries at least one time during the course of radiotherapy. No consistent relation of this variability with time was found. Bladder volumes and rectal diameters showed marked variability during the course of treatment. A large initial bladder volume and rectal diameter predicted a large volume variation and a large tumor spatial variability.
Conclusion: In this study, a margin of 1.5 to 2 cm seemed to be inadequate in 65% of the patients with respect to spatial variability. Bladder volume and rectal diameter were found to be predictive for spatial variability of a bladder tumor during concomitant boost radiotherapy.</description><subject>Biological and medical sciences</subject><subject>Bladder cancer</subject><subject>Conformal radiotherapy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Movement</subject><subject>Organ motion</subject><subject>Quality assurance</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy, Conformal - methods</subject><subject>Rectum - anatomy & histology</subject><subject>Rectum - diagnostic imaging</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Urinary Bladder - anatomy & histology</subject><subject>Urinary Bladder - diagnostic imaging</subject><subject>Urinary Bladder Neoplasms - diagnostic imaging</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - radiotherapy</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi1UBMvHT2iVS1F7CB3HcZycEEKlICFxoEjcrIk9aV05ydZOkPbf47ArOHIay_O8ntFjxj5zOOfAqx8PICrIRTp-g-I7lFzWudxjK16rJhdSPn1iqzfkkB3F-A8AOFflATvkhVRCKb5i_nbo_EyDoWzsstajtRQyHGwWyEzos-fRz31qDllc4-SWGwwOW-fdtFky-Jaa5n4MmZ2DG_5kAa0ziV7qOP2lgOvNCdvv0Ec63dVj9nj98_fVTX53_-v26vIuN6LhU25FYyRhK4WksjV1hSWgUDXywhSmJARooOEcq9QFVcpKUkJVJzCpabk4Zmfbd9dh_D9TnHTvoiHvcaBxjloJKNIklUC5BU0YYwzU6XVwPYaN5qAXzfpVs14caij0q2YtU-7LbsDc9mTfUzuvCfi6AzAmC13Awbj4zqWdy6puEnex5SjpeHYUdDRu-Q3rFv_aju6DVV4AbXmaSA</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Pos, Floris J</creator><creator>Koedooder, Kees</creator><creator>Hulshof, Maarten C.C.M</creator><creator>van Tienhoven, Geertjan</creator><creator>González González, Dionisio</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy</title><author>Pos, Floris J ; Koedooder, Kees ; Hulshof, Maarten C.C.M ; van Tienhoven, Geertjan ; González González, Dionisio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-d39c5eab535e4bc86a40a378a12c2c4ea0090911a64bc074565e35e7f3a101b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Bladder cancer</topic><topic>Conformal radiotherapy</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Movement</topic><topic>Organ motion</topic><topic>Quality assurance</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy, Conformal - methods</topic><topic>Rectum - anatomy & histology</topic><topic>Rectum - diagnostic imaging</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Urinary Bladder - anatomy & histology</topic><topic>Urinary Bladder - diagnostic imaging</topic><topic>Urinary Bladder Neoplasms - diagnostic imaging</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pos, Floris J</creatorcontrib><creatorcontrib>Koedooder, Kees</creatorcontrib><creatorcontrib>Hulshof, Maarten C.C.M</creatorcontrib><creatorcontrib>van Tienhoven, Geertjan</creatorcontrib><creatorcontrib>González González, Dionisio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pos, Floris J</au><au>Koedooder, Kees</au><au>Hulshof, Maarten C.C.M</au><au>van Tienhoven, Geertjan</au><au>González González, Dionisio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>55</volume><issue>3</issue><spage>835</spage><epage>841</epage><pages>835-841</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Purpose: To assess the spatial variability of a bladder tumor relative to the planning target volume boundaries during radical radiotherapy, and furthermore to develop strategies to reduce spatial variability.
Methods and Materials: Seventeen patients with solitary T2–T4N0M0 bladder cancer were treated with a technique delivering 40 Gy/2 Gy in 20 fractions to the whole bladder with a concomitant boost to the bladder tumor of 20 Gy in 1 Gy fractions in an overall time of 4 weeks. CT scans were made weekly, immediately after treatment, and matched with the planning CT scan. Spatial variability of the tumor, as well as bladder volume and rectal diameter, were scored for each patient each week.
Results: In 65% of patients, a part of the tumor appeared outside the planning target volume boundaries at least one time during the course of radiotherapy. No consistent relation of this variability with time was found. Bladder volumes and rectal diameters showed marked variability during the course of treatment. A large initial bladder volume and rectal diameter predicted a large volume variation and a large tumor spatial variability.
Conclusion: In this study, a margin of 1.5 to 2 cm seemed to be inadequate in 65% of the patients with respect to spatial variability. Bladder volume and rectal diameter were found to be predictive for spatial variability of a bladder tumor during concomitant boost radiotherapy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12573771</pmid><doi>10.1016/S0360-3016(02)04158-5</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Bladder cancer Conformal radiotherapy Humans Medical sciences Movement Organ motion Quality assurance Radiotherapy Dosage Radiotherapy, Conformal - methods Rectum - anatomy & histology Rectum - diagnostic imaging Time Factors Tomography, X-Ray Computed Urinary Bladder - anatomy & histology Urinary Bladder - diagnostic imaging Urinary Bladder Neoplasms - diagnostic imaging Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - radiotherapy |
| title | Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy |
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