Dose-Dependent Aspirin Hydrolysis and Platelet Aggregation in Patients with Atherosclerosis

In a double blind, randomized trial the effects of aspirin (1, 5, and 15 mg/kg) were compared with the changes in platelet aggregation at 6 and 24 hours after dosage. It is found that there is a negative correlation between aspirin hydrolysis velocity in blood and capability of aspirin to decrease p...

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Veröffentlicht in:	Journal of clinical pharmacology 1992-02, Vol.32 (2), p.133-135
Hauptverfasser:	Akopov, Sergey S., Grigorian, George S., Gabrielian, Emil S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Arteriosclerosis - metabolism Aspirin - chemistry Aspirin - metabolism Aspirin - pharmacology Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Collagen - pharmacology Dose-Response Relationship, Drug Double-Blind Method Female Humans Hydrolysis Male Medical sciences Middle Aged Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology
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