Structure and evolution of the human prosaposin chromosomal gene

The gene for prosaposin was characterized by sequence analysis of chromosomal DNA to gain insight into the evolution of this locus that encodes four highly conserved sphingolipid activator proteins or saposins. The 13 exons ranged in size from 57 to 1200 bp, while the introns were from 91 to 3812 bp...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1992-06, Vol.13 (2), p.312-318
Hauptverfasser:	Rorman, Efrat Gavrieli, Scheinker, Vladimir, Grabowski, Gregory A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Biological Evolution Crossing Over, Genetic DNA - genetics duplication Fundamental and applied biological sciences. Psychology Genes Genes. Genome Glycoproteins - genetics Humans man Mice - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Multigene Family nucleotide sequence Polymerase Chain Reaction prosaposin Protein Precursors - genetics Protein Sorting Signals - genetics rearrangement RNA Splicing Saposins Sequence Alignment Sphingolipid Activator Proteins
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