Smallest LDL Particles Are Most Strongly Related to Coronary Disease Progression in Men
OBJECTIVE—LDLs include particle subclasses that have different mobilities on polyacrylamide gradient gelsLDL-I (27.2 to 28.5 nm), LDL-IIa (26.5 to 27.2 nm), LDL-IIb (25.6 to 26.5 nm), LDL-IIIa (24.7 to 25.6 nm), LDL-IIIb (24.2 to 24.7 nm), LDL-IVa (23.3 to 24.2 nm), and LDL-IVb (22.0 to 23.3 nm in d...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2003-02, Vol.23 (2), p.314-321 |
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| container_title | Arteriosclerosis, thrombosis, and vascular biology |
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| creator | Williams, Paul T Superko, H Robert Haskell, William L Alderman, Edwin L Blanche, Patricia J Glines Holl, Laura Krauss, Ronald M |
| description | OBJECTIVE—LDLs include particle subclasses that have different mobilities on polyacrylamide gradient gelsLDL-I (27.2 to 28.5 nm), LDL-IIa (26.5 to 27.2 nm), LDL-IIb (25.6 to 26.5 nm), LDL-IIIa (24.7 to 25.6 nm), LDL-IIIb (24.2 to 24.7 nm), LDL-IVa (23.3 to 24.2 nm), and LDL-IVb (22.0 to 23.3 nm in diameter). We hypothesized that the association between smaller LDL particles and coronary artery disease (CAD) risk might involve specific LDL subclasses.
METHODS AND RESULTS—Average 4-year onstudy lipoprotein measurements were compared with annualized rates of stenosis change from baseline to 4 years in 117 men with CAD. The percentages of total LDL and HDL occurring within individual subclasses were measured by gradient gel electrophoresis. Annual rate of stenosis change was related concordantly to onstudy averages of total cholesterol (P =0.04), triglycerides (P =0.05), VLDL mass (P =0.03), total/HDL cholesterol ratio (P =0.04), LDL-IVb (P =0.01), and HDL3a (P =0.02) and inversely to HDL2-mass (P =0.02) and HDL2b (P =0.03). The average annual rate in stenosis change was 6-fold more rapid in the fourth quartile of LDL-IVb (≥5.2%) than in the first quartile ( |
| doi_str_mv | 10.1161/01.ATV.0000053385.64132.2D |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73021974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73021974</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5688-c20fe0ec97987ef3afb7b98803de48197d735ccf2ced9edd1c9131eb36b469483</originalsourceid><addsrcrecordid>eNpdkW9rFDEQxoMotp5-BQkFfbdr_u0m67vjTlvhisVWfRmy2dl2a27TJruUfnvnvIMDAyGZ4TfPZJ4QcsZZyXnNPzFeLm9-lWy3KilNVdaKS1GK9QtyyiuhClXL-iXemW6KqlbihLzJ-R5xJQR7TU64qIzRWp-S39dbFwLkiW7WG3rl0jR4DOkyAb2MmL6eUhxvwzP9AcFN0NEp0lXEnEvPdD1kcBnoVYq3CXIe4kiHkV7C-Ja86l3I8O5wLsjPr19uVhfF5vv5t9VyU_iqNqbwgvXAwDe6MRp66fpWt40xTHagDG90p2XlfS88dA10HfcNlxxaWbeqbpSRC_Jxr_uQ4uOMc9jtkD2E4EaIc7ZaMoEyCsGz_8D7OKcR32YF2mK0rCVCn_eQTzHnBL19SMMWJ7Wc2Z33lnGL3tuj9_af91assfj9ocPcbqE7lh7MRuDDAXDZu9AnN_ohH7mK4eeh6oKoPfcUwwQp_wnzEyR7By5Md7vWStasKgRjOByGBW5h5F8C3Zul</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204287363</pqid></control><display><type>article</type><title>Smallest LDL Particles Are Most Strongly Related to Coronary Disease Progression in Men</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Williams, Paul T ; Superko, H Robert ; Haskell, William L ; Alderman, Edwin L ; Blanche, Patricia J ; Glines Holl, Laura ; Krauss, Ronald M</creator><creatorcontrib>Williams, Paul T ; Superko, H Robert ; Haskell, William L ; Alderman, Edwin L ; Blanche, Patricia J ; Glines Holl, Laura ; Krauss, Ronald M</creatorcontrib><description>OBJECTIVE—LDLs include particle subclasses that have different mobilities on polyacrylamide gradient gelsLDL-I (27.2 to 28.5 nm), LDL-IIa (26.5 to 27.2 nm), LDL-IIb (25.6 to 26.5 nm), LDL-IIIa (24.7 to 25.6 nm), LDL-IIIb (24.2 to 24.7 nm), LDL-IVa (23.3 to 24.2 nm), and LDL-IVb (22.0 to 23.3 nm in diameter). We hypothesized that the association between smaller LDL particles and coronary artery disease (CAD) risk might involve specific LDL subclasses.
METHODS AND RESULTS—Average 4-year onstudy lipoprotein measurements were compared with annualized rates of stenosis change from baseline to 4 years in 117 men with CAD. The percentages of total LDL and HDL occurring within individual subclasses were measured by gradient gel electrophoresis. Annual rate of stenosis change was related concordantly to onstudy averages of total cholesterol (P =0.04), triglycerides (P =0.05), VLDL mass (P =0.03), total/HDL cholesterol ratio (P =0.04), LDL-IVb (P =0.01), and HDL3a (P =0.02) and inversely to HDL2-mass (P =0.02) and HDL2b (P =0.03). The average annual rate in stenosis change was 6-fold more rapid in the fourth quartile of LDL-IVb (≥5.2%) than in the first quartile (<2.5%, P =0.03). Stepwise multiple regression analysis showed that LDL-IVb was the single best predictor of stenosis change.
CONCLUSIONS—LDL-IVb was the single best lipoprotein predictor of increased stenosis, an unexpected result, given that LDL-IVb represents only a minor fraction of total LDL.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/01.ATV.0000053385.64132.2D</identifier><identifier>PMID: 12588777</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood Glucose ; Cardiology. Vascular system ; Coronary Angiography ; Coronary Disease - blood ; Coronary Disease - diagnostic imaging ; Coronary Disease - pathology ; Coronary heart disease ; Coronary Stenosis - blood ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - pathology ; Disease Progression ; Heart ; Humans ; Insulin - blood ; Lipids - blood ; Lipoproteins, HDL - blood ; Lipoproteins, VLDL - blood ; Male ; Medical sciences ; Middle Aged</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2003-02, Vol.23 (2), p.314-321</ispartof><rights>2003 American Heart Association, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Feb 1 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5688-c20fe0ec97987ef3afb7b98803de48197d735ccf2ced9edd1c9131eb36b469483</citedby><cites>FETCH-LOGICAL-c5688-c20fe0ec97987ef3afb7b98803de48197d735ccf2ced9edd1c9131eb36b469483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15015205$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12588777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Paul T</creatorcontrib><creatorcontrib>Superko, H Robert</creatorcontrib><creatorcontrib>Haskell, William L</creatorcontrib><creatorcontrib>Alderman, Edwin L</creatorcontrib><creatorcontrib>Blanche, Patricia J</creatorcontrib><creatorcontrib>Glines Holl, Laura</creatorcontrib><creatorcontrib>Krauss, Ronald M</creatorcontrib><title>Smallest LDL Particles Are Most Strongly Related to Coronary Disease Progression in Men</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVE—LDLs include particle subclasses that have different mobilities on polyacrylamide gradient gelsLDL-I (27.2 to 28.5 nm), LDL-IIa (26.5 to 27.2 nm), LDL-IIb (25.6 to 26.5 nm), LDL-IIIa (24.7 to 25.6 nm), LDL-IIIb (24.2 to 24.7 nm), LDL-IVa (23.3 to 24.2 nm), and LDL-IVb (22.0 to 23.3 nm in diameter). We hypothesized that the association between smaller LDL particles and coronary artery disease (CAD) risk might involve specific LDL subclasses.
METHODS AND RESULTS—Average 4-year onstudy lipoprotein measurements were compared with annualized rates of stenosis change from baseline to 4 years in 117 men with CAD. The percentages of total LDL and HDL occurring within individual subclasses were measured by gradient gel electrophoresis. Annual rate of stenosis change was related concordantly to onstudy averages of total cholesterol (P =0.04), triglycerides (P =0.05), VLDL mass (P =0.03), total/HDL cholesterol ratio (P =0.04), LDL-IVb (P =0.01), and HDL3a (P =0.02) and inversely to HDL2-mass (P =0.02) and HDL2b (P =0.03). The average annual rate in stenosis change was 6-fold more rapid in the fourth quartile of LDL-IVb (≥5.2%) than in the first quartile (<2.5%, P =0.03). Stepwise multiple regression analysis showed that LDL-IVb was the single best predictor of stenosis change.
CONCLUSIONS—LDL-IVb was the single best lipoprotein predictor of increased stenosis, an unexpected result, given that LDL-IVb represents only a minor fraction of total LDL.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - pathology</subject><subject>Coronary heart disease</subject><subject>Coronary Stenosis - blood</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - pathology</subject><subject>Disease Progression</subject><subject>Heart</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Lipids - blood</subject><subject>Lipoproteins, HDL - blood</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkW9rFDEQxoMotp5-BQkFfbdr_u0m67vjTlvhisVWfRmy2dl2a27TJruUfnvnvIMDAyGZ4TfPZJ4QcsZZyXnNPzFeLm9-lWy3KilNVdaKS1GK9QtyyiuhClXL-iXemW6KqlbihLzJ-R5xJQR7TU64qIzRWp-S39dbFwLkiW7WG3rl0jR4DOkyAb2MmL6eUhxvwzP9AcFN0NEp0lXEnEvPdD1kcBnoVYq3CXIe4kiHkV7C-Ja86l3I8O5wLsjPr19uVhfF5vv5t9VyU_iqNqbwgvXAwDe6MRp66fpWt40xTHagDG90p2XlfS88dA10HfcNlxxaWbeqbpSRC_Jxr_uQ4uOMc9jtkD2E4EaIc7ZaMoEyCsGz_8D7OKcR32YF2mK0rCVCn_eQTzHnBL19SMMWJ7Wc2Z33lnGL3tuj9_af91assfj9ocPcbqE7lh7MRuDDAXDZu9AnN_ohH7mK4eeh6oKoPfcUwwQp_wnzEyR7By5Md7vWStasKgRjOByGBW5h5F8C3Zul</recordid><startdate>200302</startdate><enddate>200302</enddate><creator>Williams, Paul T</creator><creator>Superko, H Robert</creator><creator>Haskell, William L</creator><creator>Alderman, Edwin L</creator><creator>Blanche, Patricia J</creator><creator>Glines Holl, Laura</creator><creator>Krauss, Ronald M</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200302</creationdate><title>Smallest LDL Particles Are Most Strongly Related to Coronary Disease Progression in Men</title><author>Williams, Paul T ; Superko, H Robert ; Haskell, William L ; Alderman, Edwin L ; Blanche, Patricia J ; Glines Holl, Laura ; Krauss, Ronald M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5688-c20fe0ec97987ef3afb7b98803de48197d735ccf2ced9edd1c9131eb36b469483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - pathology</topic><topic>Coronary heart disease</topic><topic>Coronary Stenosis - blood</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Coronary Stenosis - pathology</topic><topic>Disease Progression</topic><topic>Heart</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Lipids - blood</topic><topic>Lipoproteins, HDL - blood</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Paul T</creatorcontrib><creatorcontrib>Superko, H Robert</creatorcontrib><creatorcontrib>Haskell, William L</creatorcontrib><creatorcontrib>Alderman, Edwin L</creatorcontrib><creatorcontrib>Blanche, Patricia J</creatorcontrib><creatorcontrib>Glines Holl, Laura</creatorcontrib><creatorcontrib>Krauss, Ronald M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Paul T</au><au>Superko, H Robert</au><au>Haskell, William L</au><au>Alderman, Edwin L</au><au>Blanche, Patricia J</au><au>Glines Holl, Laura</au><au>Krauss, Ronald M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smallest LDL Particles Are Most Strongly Related to Coronary Disease Progression in Men</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2003-02</date><risdate>2003</risdate><volume>23</volume><issue>2</issue><spage>314</spage><epage>321</epage><pages>314-321</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>OBJECTIVE—LDLs include particle subclasses that have different mobilities on polyacrylamide gradient gelsLDL-I (27.2 to 28.5 nm), LDL-IIa (26.5 to 27.2 nm), LDL-IIb (25.6 to 26.5 nm), LDL-IIIa (24.7 to 25.6 nm), LDL-IIIb (24.2 to 24.7 nm), LDL-IVa (23.3 to 24.2 nm), and LDL-IVb (22.0 to 23.3 nm in diameter). We hypothesized that the association between smaller LDL particles and coronary artery disease (CAD) risk might involve specific LDL subclasses.
METHODS AND RESULTS—Average 4-year onstudy lipoprotein measurements were compared with annualized rates of stenosis change from baseline to 4 years in 117 men with CAD. The percentages of total LDL and HDL occurring within individual subclasses were measured by gradient gel electrophoresis. Annual rate of stenosis change was related concordantly to onstudy averages of total cholesterol (P =0.04), triglycerides (P =0.05), VLDL mass (P =0.03), total/HDL cholesterol ratio (P =0.04), LDL-IVb (P =0.01), and HDL3a (P =0.02) and inversely to HDL2-mass (P =0.02) and HDL2b (P =0.03). The average annual rate in stenosis change was 6-fold more rapid in the fourth quartile of LDL-IVb (≥5.2%) than in the first quartile (<2.5%, P =0.03). Stepwise multiple regression analysis showed that LDL-IVb was the single best predictor of stenosis change.
CONCLUSIONS—LDL-IVb was the single best lipoprotein predictor of increased stenosis, an unexpected result, given that LDL-IVb represents only a minor fraction of total LDL.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>12588777</pmid><doi>10.1161/01.ATV.0000053385.64132.2D</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1079-5642 |
| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2003-02, Vol.23 (2), p.314-321 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Aged Biological and medical sciences Blood Glucose Cardiology. Vascular system Coronary Angiography Coronary Disease - blood Coronary Disease - diagnostic imaging Coronary Disease - pathology Coronary heart disease Coronary Stenosis - blood Coronary Stenosis - diagnostic imaging Coronary Stenosis - pathology Disease Progression Heart Humans Insulin - blood Lipids - blood Lipoproteins, HDL - blood Lipoproteins, VLDL - blood Male Medical sciences Middle Aged |
| title | Smallest LDL Particles Are Most Strongly Related to Coronary Disease Progression in Men |
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