Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site

The adjacent insulin-like growth factor 2 (IGF2) and H19 genes are imprinted in most normal human tissues, but imprinting is often lost in tumors. The mechanisms involved in maintenance of imprinting (MOI) and loss of imprinting (LOI) are unresolved. We show here that osteosarcoma (OS) tumors with I...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2003-03, Vol.12 (5), p.535-549
Hauptverfasser:	Ulaner, Gary A., Vu, Thanh H., Li, Tao, Hu, Ji-Fan, Yao, Xiao-Ming, Yang, Youwen, Gorlick, Richard, Meyers, Paul, Healey, John, Ladanyi, Marc, Hoffman, Andrew R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics Biological and medical sciences CCCTC-Binding Factor Classical genetics, quantitative genetics, hybrids Diseases of the osteoarticular system DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genomic Imprinting Humans Insulin-Like Growth Factor II - genetics Medical sciences Osteosarcoma - genetics Repressor Proteins RNA, Long Noncoding RNA, Untranslated - genetics Transcription Factors - metabolism Tumors of striated muscle and skeleton Vertebrata
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!