Overlapping But Nonidentical Binding Sites on CD2 for CD58 and a Second Ligand CD59

The interaction of the T cell glycoprotein CD2 with one ligand, CD58, contributes to T cell function. We have identified CD59, a glycoprotein with complement-inhibitory function, as a second physiological ligand for CD2. Antibodies to CD59 inhibit CD2-dependent T cell activation in murine T cell hyb...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1992-06, Vol.256 (5065), p.1805-1807
Hauptverfasser:	Hahn, William C., Menu, Elisabeth, Alfred L. M. Bothwell, Sims, Peter J., Bierer, Barbara E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies Antigen presenting cells Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - metabolism Binding Sites Binding sites (Biochemistry) Biological and medical sciences CD2 Antigens CD58 Antigens CD59 Antigens Cell lines Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Fundamental immunology Glycoproteins Humans Hybridomas Immunity, Cellular Immunobiology In Vitro Techniques Ligand binding (Biochemistry) Ligands Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Membrane Glycoproteins - metabolism Mice Molecules Receptors, Antigen, T-Cell - physiology Receptors, Immunologic - metabolism T cells T lymphocytes T-Lymphocytes - immunology
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