The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice

Na,K-ATPase is an ion transporter that impacts neural and glial physiology by direct electrogenic activity and the modulation of ion gradients. Its three isoforms in brain have cell-type and development-specific expression patterns. Interestingly, our studies demonstrate that in late gestation, the...

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Veröffentlicht in:	The Journal of biological chemistry 2003-02, Vol.278 (7), p.5317-5324
Hauptverfasser:	Moseley, Amy E, Lieske, Steve P, Wetzel, Randall K, James, Paul F, He, Suiwen, Shelly, Daniel A, Paul, Richard J, Boivin, Gregory P, Witte, David P, Ramirez, Jan Marino, Sweadner, Kathleen J, Lingrel, Jerry B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Brain - enzymology Brain - growth & development Electrophysiology Gene Expression Regulation, Developmental Isoenzymes - biosynthesis Isoenzymes - genetics Mice Neurons - enzymology Neurons - physiology Sodium-Potassium-Exchanging ATPase - biosynthesis Sodium-Potassium-Exchanging ATPase - genetics
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