Affinity extraction combined with stable isotope dilution LC/MS for the determination of 5-methyltetrahydrofolate in human plasma

The predominant circulating folate monoglutamate in human plasma (>90%), and thus the most significant folate for accurately diagnosing folate deficiency, is 5-methyltetrahydrofolic acid (5MT). Folate deficiency is typically indicated when circulating folate levels are ⩽3 ng/mL. The quantitative...

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Veröffentlicht in:	Analytical biochemistry 2003-02, Vol.313 (1), p.117-127
Hauptverfasser:	Nelson, Bryant C, Pfeiffer, Christine M, Margolis, Sam A, Nelson, Chad P
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methyltetrahydrofolate Affinity extraction Carbon Isotopes Carrier Proteins Chromatography, Liquid - methods Folate binding protein Folate Receptors, GPI-Anchored Folates Human plasma Isotope-dilution Liquid chromatography Mass Spectrometry Mass Spectrometry - methods Receptors, Cell Surface Tetrahydrofolates - analysis Tetrahydrofolates - blood Tetrahydrofolates - isolation & purification
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