Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice

Colorectal distension (CRD) is a well-characterized model of visceral nociception, which we adapted to the mouse. CRD reproducibly evoked contractions of the abdominal musculature [visceromotor response (VMR)], which was graded to stimulus intensity. The magnitude of VMR was greater in male C57BL6 a...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2003-03, Vol.284 (3), p.G434-G444
Hauptverfasser:	Kamp, Elizabeth H, Jones, 3rd, R Carter W, Tillman, Shelly R, Gebhart, G F
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Catheterization Colitis - pathology Colitis - physiopathology Colon - innervation Colon - physiology Dose-Response Relationship, Drug Electromyography Female Hyperalgesia - physiopathology Intestinal Mucosa - pathology Male Mice Mice, Inbred Strains Morphine - pharmacology Muscle Contraction - physiology Muscle, Smooth - pathology Muscle, Smooth - physiopathology Nociceptors - physiology Pain Measurement Peroxidase - metabolism Physical Stimulation Pregnancy Rectum - innervation Rectum - physiology Restraint, Physical Sex Characteristics Species Specificity
Online-Zugang:	Volltext
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