Selected contribution: Ventilatory response to CO2 in high-altitude natives and patients with chronic mountain sickness
The ventilatory responses to CO(2) of high-altitude (HA) natives and patients with chronic mountain sickness (CMS) were studied and compared with sea-level (SL) natives living at SL. A multifrequency binary sequence (MFBS) in end-tidal Pco(2) was employed to separate the fast (peripheral) and slow (...
Gespeichert in:
| Veröffentlicht in: | Journal of applied physiology (1985) 2003-03, Vol.94 (3), p.1279-87; discussion 1253-4 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 87; discussion 1253-4 |
|---|---|
| container_issue | 3 |
| container_start_page | 1279 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 94 |
| creator | Fatemian, Marzieh Gamboa, Alfredo Léon-Velarde, Fabiola Rivera-Ch, Maria Palacios, Jose-Antonio Robbins, Peter A |
| description | The ventilatory responses to CO(2) of high-altitude (HA) natives and patients with chronic mountain sickness (CMS) were studied and compared with sea-level (SL) natives living at SL. A multifrequency binary sequence (MFBS) in end-tidal Pco(2) was employed to separate the fast (peripheral) and slow (central) components of the chemoreflex response. MFBS was imposed against a background of both euoxia (end-tidal Po(2) of 100 Torr) and hypoxia (52.5 Torr). Both total and central chemoreflex sensitivity to CO(2) in euoxia were higher in HA and CMS subjects compared with SL subjects. Peripheral chemoreflex sensitivity to CO(2) in euoxia was higher in HA subjects than in SL subjects. Hypoxia induced a greater increase in total chemoreflex sensitivity to CO(2) in SL subjects than in HA and CMS subjects, but peripheral chemoreflex sensitivity to CO(2) in hypoxia was no greater in SL subjects than in HA and CMS subjects. Values for the slow (central) time constant were significantly greater for HA and CMS subjects than for SL subjects. |
| doi_str_mv | 10.1152/japplphysiol.00859.2002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_73016911</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>692046701</sourcerecordid><originalsourceid>FETCH-LOGICAL-p149t-ed6c750df3304c3e2c242e95c7e919a1d710f9b9412dbce65c28a850a69bd98b3</originalsourceid><addsrcrecordid>eNpdkMtOwzAQRS0EoqXwC2CxYJdiO3ESs0MVL6lSFzy2kWNPiUtqB9uh6t9jCdgwmxlpzr26MwhdUDKnlLPrjRyGfuj2wbh-TkjNxZwRwg7QNG1ZRktCD9G0rjjJKl5XE3QSwoYQWhScHqMJZbxKPmSKds_Qg4qgsXI2etOO0Th7g9_ARtPL6PweewiDswFwdHixYthY3Jn3LpN9NHHUgK2M5gsCllbjIc1JG_DOxA6rzjtrFN660UaZhMGoDwshnKKjtewDnP32GXq9v3tZPGbL1cPT4naZDbQQMQNdqnSEXuc5KVQOTLGCgeCqAkGFpLqiZC1aUVCmWwUlV6yWNSeyFK0WdZvP0NWP7-Dd5wghNlsTFPS9tODG0FQ5oaWgNIGX_8CNG71N2RqWilSC8ASd_0JjuwXdDN5spd83f__MvwHHCn0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222207905</pqid></control><display><type>article</type><title>Selected contribution: Ventilatory response to CO2 in high-altitude natives and patients with chronic mountain sickness</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Fatemian, Marzieh ; Gamboa, Alfredo ; Léon-Velarde, Fabiola ; Rivera-Ch, Maria ; Palacios, Jose-Antonio ; Robbins, Peter A</creator><creatorcontrib>Fatemian, Marzieh ; Gamboa, Alfredo ; Léon-Velarde, Fabiola ; Rivera-Ch, Maria ; Palacios, Jose-Antonio ; Robbins, Peter A</creatorcontrib><description>The ventilatory responses to CO(2) of high-altitude (HA) natives and patients with chronic mountain sickness (CMS) were studied and compared with sea-level (SL) natives living at SL. A multifrequency binary sequence (MFBS) in end-tidal Pco(2) was employed to separate the fast (peripheral) and slow (central) components of the chemoreflex response. MFBS was imposed against a background of both euoxia (end-tidal Po(2) of 100 Torr) and hypoxia (52.5 Torr). Both total and central chemoreflex sensitivity to CO(2) in euoxia were higher in HA and CMS subjects compared with SL subjects. Peripheral chemoreflex sensitivity to CO(2) in euoxia was higher in HA subjects than in SL subjects. Hypoxia induced a greater increase in total chemoreflex sensitivity to CO(2) in SL subjects than in HA and CMS subjects, but peripheral chemoreflex sensitivity to CO(2) in hypoxia was no greater in SL subjects than in HA and CMS subjects. Values for the slow (central) time constant were significantly greater for HA and CMS subjects than for SL subjects.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00859.2002</identifier><identifier>PMID: 12571150</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Adult ; Altitude ; Altitude Sickness - physiopathology ; Carbon dioxide ; Carbon Dioxide - blood ; Carbon Dioxide - pharmacology ; Central Nervous System - drug effects ; Chemoreceptor Cells - drug effects ; Female ; Humans ; Male ; Models, Biological ; Native peoples ; Oxygen - blood ; Peripheral Nervous System - drug effects ; Reflex - drug effects ; Respiratory diseases ; Respiratory Mechanics - drug effects ; Respiratory Mechanics - physiology ; Respiratory system</subject><ispartof>Journal of applied physiology (1985), 2003-03, Vol.94 (3), p.1279-87; discussion 1253-4</ispartof><rights>Copyright American Physiological Society Mar 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12571150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fatemian, Marzieh</creatorcontrib><creatorcontrib>Gamboa, Alfredo</creatorcontrib><creatorcontrib>Léon-Velarde, Fabiola</creatorcontrib><creatorcontrib>Rivera-Ch, Maria</creatorcontrib><creatorcontrib>Palacios, Jose-Antonio</creatorcontrib><creatorcontrib>Robbins, Peter A</creatorcontrib><title>Selected contribution: Ventilatory response to CO2 in high-altitude natives and patients with chronic mountain sickness</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>The ventilatory responses to CO(2) of high-altitude (HA) natives and patients with chronic mountain sickness (CMS) were studied and compared with sea-level (SL) natives living at SL. A multifrequency binary sequence (MFBS) in end-tidal Pco(2) was employed to separate the fast (peripheral) and slow (central) components of the chemoreflex response. MFBS was imposed against a background of both euoxia (end-tidal Po(2) of 100 Torr) and hypoxia (52.5 Torr). Both total and central chemoreflex sensitivity to CO(2) in euoxia were higher in HA and CMS subjects compared with SL subjects. Peripheral chemoreflex sensitivity to CO(2) in euoxia was higher in HA subjects than in SL subjects. Hypoxia induced a greater increase in total chemoreflex sensitivity to CO(2) in SL subjects than in HA and CMS subjects, but peripheral chemoreflex sensitivity to CO(2) in hypoxia was no greater in SL subjects than in HA and CMS subjects. Values for the slow (central) time constant were significantly greater for HA and CMS subjects than for SL subjects.</description><subject>Adult</subject><subject>Altitude</subject><subject>Altitude Sickness - physiopathology</subject><subject>Carbon dioxide</subject><subject>Carbon Dioxide - blood</subject><subject>Carbon Dioxide - pharmacology</subject><subject>Central Nervous System - drug effects</subject><subject>Chemoreceptor Cells - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Native peoples</subject><subject>Oxygen - blood</subject><subject>Peripheral Nervous System - drug effects</subject><subject>Reflex - drug effects</subject><subject>Respiratory diseases</subject><subject>Respiratory Mechanics - drug effects</subject><subject>Respiratory Mechanics - physiology</subject><subject>Respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtOwzAQRS0EoqXwC2CxYJdiO3ESs0MVL6lSFzy2kWNPiUtqB9uh6t9jCdgwmxlpzr26MwhdUDKnlLPrjRyGfuj2wbh-TkjNxZwRwg7QNG1ZRktCD9G0rjjJKl5XE3QSwoYQWhScHqMJZbxKPmSKds_Qg4qgsXI2etOO0Th7g9_ARtPL6PweewiDswFwdHixYthY3Jn3LpN9NHHUgK2M5gsCllbjIc1JG_DOxA6rzjtrFN660UaZhMGoDwshnKKjtewDnP32GXq9v3tZPGbL1cPT4naZDbQQMQNdqnSEXuc5KVQOTLGCgeCqAkGFpLqiZC1aUVCmWwUlV6yWNSeyFK0WdZvP0NWP7-Dd5wghNlsTFPS9tODG0FQ5oaWgNIGX_8CNG71N2RqWilSC8ASd_0JjuwXdDN5spd83f__MvwHHCn0A</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>Fatemian, Marzieh</creator><creator>Gamboa, Alfredo</creator><creator>Léon-Velarde, Fabiola</creator><creator>Rivera-Ch, Maria</creator><creator>Palacios, Jose-Antonio</creator><creator>Robbins, Peter A</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>Selected contribution: Ventilatory response to CO2 in high-altitude natives and patients with chronic mountain sickness</title><author>Fatemian, Marzieh ; Gamboa, Alfredo ; Léon-Velarde, Fabiola ; Rivera-Ch, Maria ; Palacios, Jose-Antonio ; Robbins, Peter A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p149t-ed6c750df3304c3e2c242e95c7e919a1d710f9b9412dbce65c28a850a69bd98b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Altitude</topic><topic>Altitude Sickness - physiopathology</topic><topic>Carbon dioxide</topic><topic>Carbon Dioxide - blood</topic><topic>Carbon Dioxide - pharmacology</topic><topic>Central Nervous System - drug effects</topic><topic>Chemoreceptor Cells - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Native peoples</topic><topic>Oxygen - blood</topic><topic>Peripheral Nervous System - drug effects</topic><topic>Reflex - drug effects</topic><topic>Respiratory diseases</topic><topic>Respiratory Mechanics - drug effects</topic><topic>Respiratory Mechanics - physiology</topic><topic>Respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fatemian, Marzieh</creatorcontrib><creatorcontrib>Gamboa, Alfredo</creatorcontrib><creatorcontrib>Léon-Velarde, Fabiola</creatorcontrib><creatorcontrib>Rivera-Ch, Maria</creatorcontrib><creatorcontrib>Palacios, Jose-Antonio</creatorcontrib><creatorcontrib>Robbins, Peter A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fatemian, Marzieh</au><au>Gamboa, Alfredo</au><au>Léon-Velarde, Fabiola</au><au>Rivera-Ch, Maria</au><au>Palacios, Jose-Antonio</au><au>Robbins, Peter A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selected contribution: Ventilatory response to CO2 in high-altitude natives and patients with chronic mountain sickness</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2003-03</date><risdate>2003</risdate><volume>94</volume><issue>3</issue><spage>1279</spage><epage>87; discussion 1253-4</epage><pages>1279-87; discussion 1253-4</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>The ventilatory responses to CO(2) of high-altitude (HA) natives and patients with chronic mountain sickness (CMS) were studied and compared with sea-level (SL) natives living at SL. A multifrequency binary sequence (MFBS) in end-tidal Pco(2) was employed to separate the fast (peripheral) and slow (central) components of the chemoreflex response. MFBS was imposed against a background of both euoxia (end-tidal Po(2) of 100 Torr) and hypoxia (52.5 Torr). Both total and central chemoreflex sensitivity to CO(2) in euoxia were higher in HA and CMS subjects compared with SL subjects. Peripheral chemoreflex sensitivity to CO(2) in euoxia was higher in HA subjects than in SL subjects. Hypoxia induced a greater increase in total chemoreflex sensitivity to CO(2) in SL subjects than in HA and CMS subjects, but peripheral chemoreflex sensitivity to CO(2) in hypoxia was no greater in SL subjects than in HA and CMS subjects. Values for the slow (central) time constant were significantly greater for HA and CMS subjects than for SL subjects.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>12571150</pmid><doi>10.1152/japplphysiol.00859.2002</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2003-03, Vol.94 (3), p.1279-87; discussion 1253-4 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73016911 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Altitude Altitude Sickness - physiopathology Carbon dioxide Carbon Dioxide - blood Carbon Dioxide - pharmacology Central Nervous System - drug effects Chemoreceptor Cells - drug effects Female Humans Male Models, Biological Native peoples Oxygen - blood Peripheral Nervous System - drug effects Reflex - drug effects Respiratory diseases Respiratory Mechanics - drug effects Respiratory Mechanics - physiology Respiratory system |
| title | Selected contribution: Ventilatory response to CO2 in high-altitude natives and patients with chronic mountain sickness |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T21%3A51%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Selected%20contribution:%20Ventilatory%20response%20to%20CO2%20in%20high-altitude%20natives%20and%20patients%20with%20chronic%20mountain%20sickness&rft.jtitle=Journal%20of%20applied%20physiology%20(1985)&rft.au=Fatemian,%20Marzieh&rft.date=2003-03&rft.volume=94&rft.issue=3&rft.spage=1279&rft.epage=87;%20discussion%201253-4&rft.pages=1279-87;%20discussion%201253-4&rft.issn=8750-7587&rft.eissn=1522-1601&rft_id=info:doi/10.1152/japplphysiol.00859.2002&rft_dat=%3Cproquest_pubme%3E692046701%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222207905&rft_id=info:pmid/12571150&rfr_iscdi=true |