Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives

Benzothiazole side chains featured in zopolrestat (1a) and its congeners were incorporated into oxophthalazineacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety. Potent aldose reductase inhibition activity among resulting compounds is...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-06, Vol.35 (12), p.2155-2162
Hauptverfasser:	Mylari, Banavara L, Zembrowski, William J, Beyer, Thomas A, Aldinger, Charles E, Siegel, Todd W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemical synthesis Acetates - pharmacology Aldehyde Reductase - antagonists & inhibitors Animals Benzothiazoles Binding Sites Chemistry Diabetes Mellitus, Experimental - metabolism Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Humans Indazoles - chemical synthesis Indazoles - pharmacology Organic chemistry Preparations and properties Pyridazines - chemical synthesis Pyridazines - pharmacology Rats Sciatic Nerve - drug effects Sciatic Nerve - metabolism Sorbitol - metabolism Thiazoles - chemical synthesis Thiazoles - pharmacology
Online-Zugang:	Volltext
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