Tissue Microarray Analysis of Signal Transducers and Activators of Transcription 3 (Stat3) and Phospho-Stat3 (Tyr705) in Node-negative Breast Cancer Shows Nuclear Localization Is Associated with a Better Prognosis

Purpose: Although a high frequency of tumors contain constitutively activated signal transducers and activators of transcription 3 (Stat3), its relationship to breast cancer and patient survival has not been determined in a large retrospective study of node-negative tumors. To further elucidate the...

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Veröffentlicht in:	Clinical cancer research 2003-02, Vol.9 (2), p.594-600
Hauptverfasser:	DOLLED-FILHART, Marisa, CAMP, Robert L, KOWALSKI, Diane P, SMITH, Bradley L, RIMM, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - analysis Biological and medical sciences Biomarkers - analysis Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cell Nucleus - metabolism Cell Nucleus - pathology DNA-Binding Proteins - metabolism Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Lymphatic Metastasis Mammary gland diseases Medical sciences Multivariate Analysis Phosphorylation Phosphotyrosine - analysis Prognosis Proportional Hazards Models STAT3 Transcription Factor Survival Analysis Time Factors Trans-Activators - metabolism Tumors
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