Monoclonal Gammopathy and Spurious Hypophosphatemia

Spuriously low levels of plasma phosphate have been reported previously in patients with multiple myeloma and polyclonal gammopathy. We report 2 cases of spurious hypophosphatemia in patients with elevated concentrations of serum monoclonal immunoglobulins, 1 of whom had monoclonal gammopathy of und...

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Veröffentlicht in:	The American journal of the medical sciences 2003-02, Vol.325 (2), p.98-100
Hauptverfasser:	Weisbord, Steven D., Chaudhuri, Anita, Blauth, Kathleen, DeRubertis, Frederick R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Diagnosis, Differential Hematologic and hematopoietic diseases Humans Hypophosphatemia - etiology Immunoglobulins - blood Male Medical sciences Metabolic diseases Metals (hemochromatosis...) Monoclonal gammopathy Multiple Myeloma - diagnosis Multiple Myeloma - metabolism Other diseases. Hematologic involvement in other diseases Other metabolic disorders Paraproteinemias - complications Paraproteinemias - diagnosis Paraproteinemias - metabolism Phosphates - blood Spurious hypophosphatemia
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Zusammenfassung:	Spuriously low levels of plasma phosphate have been reported previously in patients with multiple myeloma and polyclonal gammopathy. We report 2 cases of spurious hypophosphatemia in patients with elevated concentrations of serum monoclonal immunoglobulins, 1 of whom had monoclonal gammopathy of undetermined significance and the other multiple myeloma. Plasma phosphate concentrations were measured using nondeproteinized and deproteinized plasma samples from patients with monoclonal gammopathies. In 2 patients with monoclonal gammopathy, the levels of plasma inorganic phosphate were reported as
ISSN:	0002-9629 1538-2990
DOI:	10.1097/00000441-200302000-00007