Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans

IgG is the most abundant serum antibody and is an essential component of the humoral immune response. It is known that the ‘neonatal’ Fc receptor (FcRn) plays a role in maintaining constant serum IgG levels by acting as a protective receptor which binds and salvages IgG from degradation. However, th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunology 2003-02, Vol.15 (2), p.187-195
Hauptverfasser:	Ward, E. Sally, Zhou, Jinchun, Ghetie, Victor, Ober, Raimund J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Affinity FcRn Histocompatibility Antigens Class I Homeostasis - immunology Homeostasis - physiology human IgG1 Humans immunodeficiency Immunoglobulin G - blood Immunoglobulin G - metabolism lysosomal trafficking Receptors, Fc - immunology Receptors, Fc - metabolism Serum - immunology Serum - metabolism serum persistence
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!