Cyclin D1 Genotype, Response to Biochemoprevention, and Progression Rate to Upper Aerodigestive Tract Cancer

Background: Altered cyclin D1 expression in advanced preinvasive lesions of the upper aerodigestive tract (UADT) is associated with an increased risk of developing cancer and histologic progression during and after combination biochemopreventive therapy (13-cis-retinoic acid, α-interferon, and α-toc...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2003-02, Vol.95 (3), p.198-205
Hauptverfasser:	Izzo, Julie G., Papadimitrakopoulou, Vassiliki A., Liu, Diane D., den Hollander, Petra L. C., Babenko, Ilona M., Keck, Jamie, El-Naggar, Adel K., Shin, Dong M., Lee, J. Jack, Hong, Waun K., Hittelman, Walter N.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - administration & dosage Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cancer Chemotherapy Cyclin D1 - blood Cyclin D1 - genetics Digestive system Disease Progression Gene Expression Regulation, Neoplastic Genotype Humans Immunohistochemistry Immunologic Factors - therapeutic use In Situ Hybridization, Fluorescence Interferon-alpha - administration & dosage Isotretinoin - administration & dosage Laryngeal Neoplasms - blood Laryngeal Neoplasms - genetics Laryngeal Neoplasms - pathology Laryngeal Neoplasms - prevention & control Medical sciences Mouth Neoplasms - blood Mouth Neoplasms - genetics Mouth Neoplasms - pathology Mouth Neoplasms - prevention & control Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Prevention Prospective Studies Treatment Outcome Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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