Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder
Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so‐called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we...
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| Veröffentlicht in: | British journal of haematology 2003-02, Vol.120 (4), p.691-694 |
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| container_title | British journal of haematology |
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| creator | Pardanani, Animesh Kimlinger, Teresa K. Reeder, Terra L. Li, Chin‐Yang Tefferi, Ayalew |
| description | Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so‐called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0·04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients. |
| doi_str_mv | 10.1046/j.1365-2141.2003.04125.x |
| format | Article |
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Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0·04). 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Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0·04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients.</description><subject>Antigens, Neoplasm - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Bone Marrow Cells - metabolism</subject><subject>CD2 Antigens - metabolism</subject><subject>CD2 expression</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematologic Diseases - metabolism</subject><subject>Hematology</subject><subject>Humans</subject><subject>mast cells</subject><subject>Mast Cells - metabolism</subject><subject>Mastocytosis, Systemic - metabolism</subject><subject>Medical sciences</subject><subject>Other diseases. 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Hematologic involvement in other diseases</topic><topic>Prospective Studies</topic><topic>Receptors, Interleukin-2 - metabolism</topic><topic>systemic mast cell disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pardanani, Animesh</creatorcontrib><creatorcontrib>Kimlinger, Teresa K.</creatorcontrib><creatorcontrib>Reeder, Terra L.</creatorcontrib><creatorcontrib>Li, Chin‐Yang</creatorcontrib><creatorcontrib>Tefferi, Ayalew</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pardanani, Animesh</au><au>Kimlinger, Teresa K.</au><au>Reeder, Terra L.</au><au>Li, Chin‐Yang</au><au>Tefferi, Ayalew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2003-02</date><risdate>2003</risdate><volume>120</volume><issue>4</issue><spage>691</spage><epage>694</epage><pages>691-694</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so‐called reactive mast cells. 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| ispartof | British journal of haematology, 2003-02, Vol.120 (4), p.691-694 |
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| subjects | Antigens, Neoplasm - metabolism Biological and medical sciences Biomarkers, Tumor - metabolism Bone Marrow Cells - metabolism CD2 Antigens - metabolism CD2 expression Hematologic and hematopoietic diseases Hematologic Diseases - metabolism Hematology Humans mast cells Mast Cells - metabolism Mastocytosis, Systemic - metabolism Medical sciences Other diseases. Hematologic involvement in other diseases Prospective Studies Receptors, Interleukin-2 - metabolism systemic mast cell disease |
| title | Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder |
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